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舒胆通颗粒防治胆石症的实验研究
引用本文:陆红,张信岳,刘芳芳,刘萍,金少圣.舒胆通颗粒防治胆石症的实验研究[J].中国临床药理学与治疗学,2009,14(9):1028-1031.
作者姓名:陆红  张信岳  刘芳芳  刘萍  金少圣
作者单位:1. 浙江中医药大学药学院,杭州,310053,浙江
2. 浙江医药学科学院药物研究所,杭州,310013,浙江
基金项目:浙江省中管局资助项目 
摘    要:目的:观察舒胆通颗粒对豚鼠实验性胆石症的防治作用。方法:62只DHA系豚鼠随机分为正常组、模型对照组、阳性对照组(复方胆通胶囊,0.6 g/kg)以及舒胆通颗粒5、10、20 g(按生药量折算,下同)/kg剂量组,除正常组外均采用高胆固醇低蛋白致石饲料喂养复制胆石症模型,同时灌胃给药连续70 d,观察豚鼠一般状况、结石形成、胆汁分泌及其成分、血液生化等方面的变化。结果:舒胆通颗粒5、10、20 g/kg剂量能明显改善胆石症豚鼠一般状况,降低结石形成比率,提高胆汁中总胆汁酸(TBA)含量,10、20 g/kg并能明显提高胆汁分泌量以及血浆胆囊收缩素(CCK)含量,降低血清TC水平。结论:舒胆通颗粒对胆石症豚鼠模型有较好的防治作用。

关 键 词:舒胆通颗粒  胆石症  防治作用  实验研究

Experimental study on Shu Dan Tong granules in prevention and frcatment effects of cholelithiasis
LU Hong,ZHANG Xin-yue,LIU Fang-fang,LIU Ping,JIN Shao-sheng.Experimental study on Shu Dan Tong granules in prevention and frcatment effects of cholelithiasis[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2009,14(9):1028-1031.
Authors:LU Hong  ZHANG Xin-yue  LIU Fang-fang  LIU Ping  JIN Shao-sheng
Affiliation:1School of Pharmacy , Zhejiang University of Chinese Medicine, Hangzhou 310053, Zhejiang , China ; 2Institute of Materia Medica, Zhejiang Academy of Medical Sciences, Hangzhou 310013, Zhejiang, China)
Abstract:AIM: To observe the prevention and cure effects of Shu Dan Tong granules(SDT) on experi-mental cholelithiasis in guinea pigs. METHODS:62 DHA guinea pigs were randomly divided into normal group, model control group, positive control group, as well as SDT 5,10,20 g (crude drug, the same below)/ kg dose group, feed with high cholesterol and low pro-tein lithogenic diet in addition to the normal group, and all guinea pigs in different group were given corre-sponding drugs simultaneously by gavage administration for 70 days, and the general condition, stone formation, bile secretion and composition, blood biochemistry were observerd or detected. RESULTS: SDT can significantly improve the general condition of cholelithiasis in guinea pigs, lower lithogenesis rate and improve total bile acid (TBA) content in doses of 5,10, 20 g/kg, and can significantly improve the bile secretion and plasma cholecystokinin (CCK) levels, lower serum total cholesterol (TC) levels in doses of 10, 20 g/kg. CONCLUSION: SDT has the prevention and cure effects on cholelithiasis modle of guinea pigs.
Keywords:Shu Dan Tong granules  cholelithiasis  prevention and cure effects  experimental study
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