对比剂首过MR灌注成像在脑胶质瘤中的应用价值

对比剂首过MR灌注成像是近年来发展较快的技术,其在脑卒中的价值已经确立.血管生成是恶性肿瘤的生长与转移的病理学基础,且与肿瘤的分级有密切关系,MR灌注成像能无创性检测瘤内的血流动力学改变,可以反映血管生成的情况,因此在脑胶质肿瘤中的应用也得到关注,其在胶质瘤分级、指导立体定向活检、检测治疗效果及鉴别诊断中有常规MRI无法取代的优势.本文从其在胶质瘤中的理论研究背景、技术及其临床应用角度分析其研究现状.

Contrast-enhanced first pass perfusion MR imaging in glioma

Dynamic contrast enhanced first past susceptibility weighted perfusion MR imaging is a fast developing technique in recent years,which has established its role in brain stroke. Angiogenesis is the pathological basis of malignant tumor growth and metastasis,and is closely related to grade of gliomas. Perfusion MR imaging is paid attention to because it can noninvasively detect hemodynamic changes in the gliomas representing tumor's angiogenesis. It is superior to conventional MRI in grading the gliomas,guiding biopsy,monitoring treatment effects,and differentiating diagnosis. This article reviews the current status of perfusion MR imaging in the theoretical background,techniques,and clinical uses in glioma.