Chinese Medicine Improves Postoperative Quality of Life in Endometriosis Patients: A Randomized Controlled Trial |
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Authors: | ZHAO Rui-hu LIU Yong TAN Yong HAO Zeng-ping MENG Qing-wei WANG Rui LONG Di DING Yong-fen SONG Dian-rong XU Cai REN Zhi-zhen YANG Yan-huan and WANG Ai-ming |
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Institution: | 1. Shandong University of Traditional Chinese Medicine, Jinan, 250355, China 2. Department of Genecology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China 3. Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing, 210029, China 4. Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China 5. Beijing Hospital of the Ministry of Health, Beijing, 100730, China 6. Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China 7. Fuxing Hospital, Capital Medical University, Beijing, 100038, China 8. Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, 100102, China 9. The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300150, China 10. PLA Navy General Hospital, Beijing, 100048, China
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Abstract: | Objective To investigate the effect of Chinese medicine (CM) and Western medicine (WM) on quality of life (QOL) after conservative surgery for endometriosis. Methods A total of 320 patients with endometriosis were randomized into two groups by using random block design, CM group (160 cases, activating blood circulation and removing blood stasis treatment based on syndrome differentiation) and WM group (160 cases, gonadotropin-releasing hormone agonist or gestrinone treatment) after conservative surgery. Treatment was given for 3–6 months (according to the revised American Fertility Society scoring system stage), and the World Health Organization QOL-BREF (WHOQOL-BREF) was applied to patients before and after treatment to assess QOL. Results There were 136 cases in the CM group and 141 cases in the WM group completing therapy. In the CM group, the use of the WHOQOL-BREF showed that the physical, psychological and environmental scores posttreatment were significantly higher than those at pre-treatment (P<0.05), and for 12 items (pain and discomfort, energy and fatigue, sleep and rest, mobility, activities of daily living, work capacity, negative feelings, health and social care: accessibility and quality, participation in and opportunities for recreation/leisure activities, appetite, QOL score, overall health status and QOL), the difference in scores was significant (P<0.05). In the WM group, 4 items (pain and discomfort, opportunities for acquiring new information and skills, QOL score, overall health status and QOL) had significantly different scores post-treatment compared with those at pre-treatment (P<0.05). Before treatment, the QOL in the two groups of patients showed no significant difference (P>0.05). After treatment, the scores for physical health in the CM group were significantly higher than those of the WM group (P<0.05) and the scores of 4 items (mobility, activities of daily living, sexual activity, QOL score) in the CM group were significantly higher than those in the WM group (P<0.05). Conclusions CM and WM treatment could improve the QOL of patients with endometriosis after conservative surgery. CM treatment is more effective than WM. |
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Keywords: | endometriosis quality of life Chinese medicine gonadotropin-releasing hormone agonist World Health Organization QOL-BREF |
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