Beneficial effects of the heme oxygenase-1/carbon monoxide system in patients with severe sepsis/septic shock |
| |
Authors: | Shoji Takaki Naoshi Takeyama Yuka Kajita Teru Yabuki Hiroki Noguchi Yasuo Miki Yasusuke Inoue Takashi Nakagawa Hiroshi Noguchi |
| |
Institution: | 1. Department of Emergency and Critical Care Medicine, Aichi Medical University, Nagakute-cho, Aichi, Japan
|
| |
Abstract: | Purpose We evaluated the relations among the arterial carbon monoxide (CO) concentration, heme oxygenase (HO)-1 expression by monocytes, oxidative stress, plasma levels of cytokines and bilirubin, and the outcome of patients with severe sepsis or septic shock. Methods Thirty-six patients who fulfilled the criteria for severe sepsis or septic shock and 21 other patients without sepsis during their stay in the intensive care unit were studied. HO-1 protein expression by monocytes, arterial CO, oxidative stress, bilirubin, and cytokines were measured. Results Arterial blood CO, cytokine, and bilirubin levels, and monocyte HO-1 protein expression were higher in patients with severe sepsis/septic shock than in non-septic patients. Increased HO-1 expression was related to the arterial CO concentration and oxidative stress. There was a positive correlation between survival and increased HO-1 protein expression or a higher CO level. Conclusions Arterial CO and monocyte HO-1 protein expression were increased in critically ill patients, particularly those with severe sepsis or septic shock, suggesting that oxidative stress is closely related to HO-1 expression. The HO-1/CO system may play an important role in sepsis. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|