Hormontherapie bei POF-Syndrom

Premature ovarian failure refers to ovarian insufficiency with early estrogen depletion before the age of 40. Long-term risks of estrogen deficiency outweigh the risks of hormone therapy by far. Therefore, guidelines generally recommend hormonal therapy until the age of normal menopause at 51?years. Hormonal treatment can be administered as estradiol preparations with progestagens or oral contraceptive pills. Spontaneous pregnancies are rare, reported in approximately 5% of cases. No specific infertility treatment is available.