榄香烯单药或联合放化疗治疗脑恶性肿瘤的Meta分析

目的:通过Meta 分析评价榄香烯治疗脑恶性肿瘤的近期疗效和1 年生存率，并探讨榄香烯在治疗脑恶性肿瘤中的疗效。方法:通过中国知网、CBM、维普、万方以及Medline数据库，查找1980～2009年的相关文献，制定纳入和排除标准；通过Jadad量表评价纳入研究的质量，近期疗效按WHO规定的肿瘤疗效评价标准:完全缓解（CR），部分缓解（PR），稳定（NC），进展（PD）。有效=CR+PR ，无效=NC+PD ；利用RevMan4.2 软件进行Meta 分析。结果:入选5 篇文献，共有患者351 例。其中5 篇均报道了近期疗效，171 例进入治疗组，180 例进入对照组。3 篇文献报道了1 年生存率，101 例进入治疗组，105 例进入对照组。对结果进行分析后认为，无论榄香烯单药治疗还是联合放疗均有一定疗效，并能提高1 年生存率。结论:榄香烯治疗脑恶性肿瘤已显示出一定的疗效，但仍需要多中心大样本随机对照进一步验证此结果。 

Meta-Analysis of the Effect of Elemene Alone or Elemene Combined with Radiochemotherapy on Malignant Brain Tumor

Objective:To evaluate the short-term effect of elemene treatment on malignant brain tumors and to analyze patients'1-year survival rate using Meta-Analysis.Methods:We searched for related articles (1980-2009) in CNKI,CBM,VIP,Wanfang databases as well as the Medline database,and the standards of inclusion and exclusion were provided.The quality of the included study was evaluated by Jadad scale and the short-term effect was evaluated according to the re-sponse evaluation criteria in tumor provided by WHO:complete response (CR),partial response (PR),no change (NC),and progressive disease (PD).Efficacy was defined as CR/PR and inefficacy was defined as NC/PD.Revman 4.2 soft-ware was used for Meta-Analysis.Results:Five articles were adopted,and the total number of cases was 351.Short-term effect of Elemene was reported in five articles.There were 171 cases in the treatment group and 101 cases in the control group.Three articles reported 1-year survival rate.There were 101 cases in the treatment group and 105 cases in the con-trol group.Elemene alone or combined with radiotherapy improved 1-year survival rate.Conclusion:Elemene is demonstrat-ed effective in treating brain tumors,and it can be widely used.More series of controlled,perspective,randomized,dou-ble-blind,well-designed,and multi-center trials should be performed for further confirmation of the effect of Elemene on ma-lignant brain tumors.