| 大豆苷元局部麻醉作用的研究 |
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| 引用本文： | 曾靖,邱峰,叶和杨,钟睿翀,黄贤华. 大豆苷元局部麻醉作用的研究[J]. 赣南医学院学报, 2004, 24(6): 637-639 |
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| 作者姓名： | 曾靖 邱峰 叶和杨 钟睿翀 黄贤华 |
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| 作者单位： | 赣南医学院药理教研室,江西,赣州,341000;沈阳药科大学植化教研室,辽宁,沈阳,110016;赣南医学院显微实验室,江西,赣州,341000 |
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| 基金项目： | 江西省教育厅立项资助 (2 0 0 3- 2 0 0 5 ) |
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| 摘 要： | 目的：研究大豆苷元的局部麻醉作用。方法：采用蟾蜍离体坐骨神经动作电位法、豚鼠皮丘法、椎管麻醉法、表面麻醉法。结果：大豆苷元对蟾蜍离体坐骨神经动作电位可完全消失，且动作电位可恢复正常。大豆苷元有浸润麻醉作用，而且盐酸肾上腺素可明显延长大豆苷元的局麻作用时间。家兔椎管内注入大豆苷元也可产生明显的椎管内麻醉作用。大豆苷元对家兔角膜具有一定的表面麻醉作用，其表面麻醉效果较1％的普鲁卡因更弱。结果：大豆苷元有明显的局部麻醉作用。
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| 关 键 词： | 大豆苷元 普鲁卡因 |
| 文章编号： | 1001-5779(2004)06-0637-03 |
| 修稿时间： | 2004-10-10 |
A Study on Local Anesthetic Effect of Daidzein |
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| ZENG Jing ,QIU Feng ,YE He-yang ,et al. A Study on Local Anesthetic Effect of Daidzein[J]. Journal of Gannan Medical College, 2004, 24(6): 637-639 |
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| Authors: | ZENG Jing QIU Feng YE He-yang et al |
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| Affiliation: | ZENG Jing 1,QIU Feng 2,YE He-yang 1,et al |
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| Abstract: | Objective:To study the local anesthetic effect of daidzein.Methods:The conventional local anesthetic methods were used:(1)the method of the action potential of isolated sciatic nerve in toads;(2)the method of infiltration anesthesia in guinea pig;(3)the method of intravertebral anesthesia in rabbits;(4)the method of superficial anesthesia in rabbits.Results:daidzein(DD)can completely inhibit action potential of the isolated sciatic nerve in toads,but less than 1% hydrochloride procaine.It had effect of infiltration anesthesia similar to 1% procaine,and adrenalin hydrochloride can enhance its anesthetic intensity and obviously prolong the time of local anesthesia.It had effect of intravertebral anesthesia similar to 1% procaine too. But it had not the effect of superficial anesthetic.Conclusion:DD has an effect of local anesthetic. |
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| Keywords: | Daidzein local anesthetic procaine |
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