SJOGREN'S SYNDROME: ASSOCIATION WITH TYPE-1 DIABETES MELLITUS |
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| Authors: | BINDER, A. MADDISON, P. J. SKINNER, P. KURTZ, A. ISENBERG, D. A. |
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| Affiliation: | !["{dagger}"]("/math/dagger.gif") The Bloomsbury Rheumatology Unit and the Department of Rheumatology Research and the Department of Medicine
*University College and the Middlesex Hospital Medical School LondonThe Royal National Hospital for the Rheumatic Diseases Bath |
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| Abstract: | This study of 102 unselected type-1 diabetic patients has shownthat sicca symptoms affect 55% of the patients, although sometimesonly during hyperglycaemic phases. While these symptoms mightbe attributable to the diabetes, the frequency of antinuclearantibodies in those suspected of having Sjögren's (25%by HEp-2) and particularly anti-Ro antibodies (32% by ELISA)reinforces the suspicion that Sjogren's syndrome may underlietheir presence. KEY WORDS: Sicca syndrome, Autoantibodies, Anti-Ro, Hyperglycaemia, Immunoglobulins, Rheumatoid factor |
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