| 国产湿痛喜康的抗炎解热和镇痛作用 |
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| 引用本文： | 贾秀荣,焦文才,魏文树,陈敏珠,徐叔云. 国产湿痛喜康的抗炎解热和镇痛作用[J]. 中国药理学通报, 1986, 0(4) |
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| 作者姓名： | 贾秀荣 焦文才 魏文树 陈敏珠 徐叔云 |
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| 作者单位： | 华北煤碳医学院(贾秀荣)，齐齐哈尔医学院(焦文才)，福州军医学校(魏文树)，安徽医科大学临床药理研究所(陈敏珠)，安徽医科大学临床药理研究所(徐叔云) |
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| 摘 要： | 湿痛喜康对角叉菜胶诱发大鼠踝关节肿胀、二甲苯诱导小鼠耳水肿、大鼠佐剂性关节炎、酵母诱发大鼠发热、冰醋酸诱导小鼠扭体反应和“热板”致痛反应等实验模型,有明显的抗炎、解热和镇痛作用。对角叉菜胶性炎症模型和小鼠扭体反应的ED_(50)分别为5.26mg/kg和5.5mg/kg。
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| 关 键 词： | 湿痛喜康 抗炎作用 解热 镇痛 |
ANTIINFLAMMATORY, ANTIPYRETIC AND ANALGESIC EFFECTS OF SUDOXICAM |
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| Jia Xiurong,Jiao Wencai,Wei Wenshu,Chen Mingzhu , Xu Shuyun. ANTIINFLAMMATORY, ANTIPYRETIC AND ANALGESIC EFFECTS OF SUDOXICAM[J]. Chinese Pharmacological Bulletin, 1986, 0(4) |
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| Authors: | Jia Xiurong Jiao Wencai Wei Wenshu Chen Mingzhu & Xu Shuyun |
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| Abstract: | This paper describes the anti-inflammatory, antipyretic and analgesic effects of Sudoxicam ( Sud) synthesized by Shenyang Pharmaceutic College.Sud is found to possess significant anti-inflammatory, antipyretic and analgesic quality in such animal models as carrayeenan-induced paw oedema ( ED50=5.26mg/kg ) , tylolinduced ear oedema in mice, adjuvant-induced arthritis in rats, yeast-induced fever in rats, acetic acid-induced arithing ( ED50= 5.0mg/kg ) and hot plate-induced pain reaction in mice. |
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| Keywords: | Sudexicam Antiinflammatory Antipyretic Analgesic |
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