代谢综合征与颈动脉内膜中层厚度关系的研究

目的探讨代谢综合征（MS）不同组合成份与颈动脉内膜中层厚度（IMT）的关系及其C反应蛋白（C-RP）、纤维蛋白原（FIB）水平.方法115例MS患者,按组成成份不同分为MS合并2型糖尿病和高血压组（40例）、MS合并2型糖尿病（或糖耐量减低）组（41例）和MS非糖尿病组（34例）.同期检测36例年龄、性别相匹配的健康对照组.用B超高频探头测量颈动脉IMT.结果MS各亚组颈动脉IMT高于对照组（P〈0.05）,MS组颈动脉粥样硬化斑块明显增多,明显高于对照组（P〈0.05）.颈动脉IMT与年龄和糖尿病病程、FPG、2hPG、SBP、TG、LDL-C呈正相关.MS组血清C-RP、血浆FIB明显高于对照组（P〈0.05）.结论MS易引起动脉粥样硬化,随MS组分数量的增多,IMT、C-RP呈现逐渐增高的趋势,对MS患者应常规检测颈动脉IMT.

The Relationship between Metabolic Syndrome and Carotid Artery Intima-media Thickness

Objective To explore the relationship between different components of metabolic syndrome （MS） and carotid artery intima-media thickness （IMT）.To observe the level of plasma creactive protein （C-RP） and fibrinogen （FIB） in patients with metabolic syndrome.Methods 115 patients metabolic syndrome with were divided into three groups according to the different components of MS;40 patients with type 2 diabetes mellitus and hypertension,41 patients with type 2 diabetes mellitus and impaired glucose tolerance and 34 patients without diabetes mellitus.36 normal subjects served as controls.The carotid artery IMT was measured by highresolution Bmode ultrasonography.The plasma glucose and blood lipid was determined. Results Carotid artery IMT was significantly higher in the clustering of MS components than control group （P〈0.05）.The occurrences of atherosclerosis plaque was significantly higher in the clustering of MS components than control group （P 〈0.05）.In group MS, IMT was positively co rrelated with age, duration of diabetes mellitus,fasting plasma glucose, postprandial 2 h plasma glucose,systolic blood pressure,triglyceride,low density lipoprotein cholesterol.The plasma levels of C-RP and FIB were higher in patients of MS than controlgroup （P 〈0.05）.Conclusion MS tends to cause atherosclerosis.And there is a tendency of progressive increase in IMT and C-RP with increasing components of MS.The carotid artery IMT of the patients with MS should be routinely measured.