子宫内膜癌雌孕激素受体、HER-2、P53表达及意义

目的探讨子宫内膜癌雌激素受体（ER）、孕激素受体（PR）、HER-2和p53的表达及临床意义。方法应用免疫组织化学法检测162例子宫内膜癌ER、PR、HER-2、p53表达情况，分析其与组织学分级、浸润深度和淋巴结转移间的关系。结果162例子宫内膜癌中ER阳性率53．7％，PR阳性率61．1％，HER-2阳性率18．5％，p53阳性率33．3％；ER、PR的表达与内膜样腺癌的组织学分级相关，与内膜样癌的浸润深度和淋巴结转移无关，HER-2、p53的表达与内膜癌浸润深度相关，HER-2的表达与内膜癌淋巴结转移相关。结论检测ER、PR、HER-2、p53的表达，有助于评估子宫内膜癌的预后和制定个体化治疗方案。

The expression and significance of estrogen and progesterone receptor, HER-2 and p53 in endometrial carcinoma

Objective To investigate the expression and clinical significance of estrogen receptor (ER) ,progesterone receptor (PR), HER-2 and p53 in endometrial carcinoma. Methods The immunohis-tostaining of 162 cases of endometrial carcinoma was detected for ER, PR, HER-2 and 1053 expression, and the relationship between histological grade, depth of invasion and lymph node metastasis was analyzed. Results In 162 cases of endometrial carcinoma, the positive rate of ER, PR, HER2 and p53 was 53.7% ,61.1%, 18.5% and 33. 3% ,respectly. The expression of ER and PR was related to the histological grade or endometrial adeno-carcinoma,but without relationship to the invnsive depth and lymph node metastasis. The expression of HER-2 and p53 was related the invasive depth, and HER-2 expression was related lymph node metastasis. Conclusion The detection of ER, PR, HER-2 and p53 expression in endometrial carcinoma helped to access the prognosis and formulate individualized treatment programs.