恶性脑胶质瘤术后替莫唑胺同步放化疗与单纯放疗的疗效对比

目的观察脑胶质瘤患者术后单纯放疗和替莫唑胺同步放化疗的疗效。方法将2008年1月～2009年12月收治62例脑胶质瘤术后患者分成A、B两组各31例，A组（单纯放疗组）给予术后单纯放疗（DT60Gy）；B组（同步放化疗组）给予与单纯放疗组相同的放疗方法，放射治疗期间口服替莫唑胺（75mg／m^2·d）同步化学治疗，放射治疗后开始辅助化学治疗，即口服替莫唑胺150～200mg／（m^2·d），连续5天，每28天为1个疗程，共用6个周期。两组治疗过程中均根据患者情况给予地塞米松、甘露醇等降颅压治疗。结果脑胶质瘤术后同步放化疗组1、3、5年生存率分别为80．00％、50．50％和31．OO％，优于术后单纯放疗组的60．50％、25．50％和14．00％，组间差异有统计学意义（均P＜0．05）。结论脑胶质瘤患者术后同步替莫唑胺放化疗疗效优于术后单纯放疗。

Effect of postoperative radiotherapy and radiochemotherapy with temozolomide on cerebral gliomas

Objective To retrospectively study the survival of cerebral gliomas received radiotherapy and radiochemotherapy with temozolomide postoperatively. Methods 62 postoperative patients with erebral gliomass were postopera- tively treated. A group（RT group） was irradiated with DT60Gy merely and B group （RCT group） combined with chemotherapy（Temozolomide 75mg/m^2. d after radiotherapy with 4～6 cycles of chemotherapy were treated（150～200mg/m^2·d, Continued 5 days,per 28 days one cycle ）. Two groups were also treated with dexamethasone and lower ICP. Results The 1-, 3-, and 5- year survival rate of patients of RCT group was 80.00%, 50.50% and 31.00%, respectively. The 1-, 3-, and 5- year survival rate of patients of RT group was 60.50%, 25.50% and 14.00%, respectively. The difference of the survival rates between two groups was significant（P〈0.05）. Conclusion Radiochemotherapy postoperatively could significantly improved the survival rate of patients with cerebral gliomas.