~(99m)Tc-MIBI显象无创伤性诊断门静脉分流

通过直肠给药~(99m)Tc-MIEI测定门脉-系统循环短路。对8例正常对照者与58例各种肝脏疾病患者作了测定。正常对照者5min内肝影显示而其他器官放射性极少。门脉高压性肝硬化患者心影明显,其心脏与肝脏比值(H/L)明显高于正常组、急性和慢性肝炎组(P<0.01)。H/L值与茚菁绿试验(ICG)值具有良好相关。H/L值与手术直接测定门静脉压力值之间也有着明显相关性。本方法是一种实用、可靠的诊断门脉分流的手段。

EVALUATION OF PORTAL CIRCULATION WITH 99mTc-MIBI IMAGING

A new method for evaluating portal systemic circulation with administration of 99mTc-MIBI per rectum was performed in 8 healthy subjects and 58 patients with various liver diseases. In healthy controls, the liver was clearly and guickly viasualized whereas the images of other organs such as the heart, spleen and lunga were very poor. In patients with liver cirrhosis associated with portal-systemic shunt, the liver was less clearly visualized, whereas radioactivity in other organs, especially in the heart, became more evident than the healthy subjects. The heart toliver uptake ratio(H/L ratio) was significantly higher in liver cirrhosia than those of healthy subjects or pateints with acute or chronic hepatites (P< 0.01). There was a good correlation between H/L ratio and the results obtaind from indocyanine green test, as well as surgical operation. The preSoat data suggests that the 99mTc-MIBI imaging seems to be a noninvasive method Very useful in evaluating portal-systemic shunts.