| 高同型半胱氨酸血症致血管内皮功能障碍研究进展 |
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| 引用本文： | 加娜提,张向阳.高同型半胱氨酸血症致血管内皮功能障碍研究进展[J].心血管病学进展,2007,28(2):315-317. |
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| 作者姓名： | 加娜提 张向阳 |
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| 作者单位： | 新疆医科大学第一附属医院心内科,新疆,乌鲁木齐,830054 |
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| 摘 要： | 高同型半胱氨酸血症已被许多研究证实是心血管疾病的独立危险因素。高同型半胱氨酸血症可造成血管内皮功能障碍,而内皮功能障碍与诸多心血管疾病的发生、发展有着密切联系。与同型半胱氨酸代谢相关的酶的基因突变及营养性B族维生素(叶酸、维生素B12、维生素B6)缺乏均可造成高同型半胱氨酸血症。B族维生素可通过降低血浆同型半胱氨酸水平改善内皮功能。
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| 关 键 词： | 同型半胱氨酸 内皮功能障碍 叶酸 维生素B12 维生素B6 |
| 文章编号： | 1004-3934(2007)02-0315-03 |
| 修稿时间： | 2006-08-25 |
Endothelial Dysfunction Induced by Hyperhomocysteinemia |
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| JIA Na-ti,ZHANG Xiang-yang.Endothelial Dysfunction Induced by Hyperhomocysteinemia[J].Advances in Cardiovascular Diseases,2007,28(2):315-317. |
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| Authors: | JIA Na-ti ZHANG Xiang-yang |
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| Abstract: | The results of numerous studies have established that hyperhomocysteinemia is an independent risk factor for cardiovascular disease.Hyperhomocysteinemia induces endothelial dysfunction.Endothelial dysfunction is closely related to the occurrence and progress of many cardiovascular diseases.Gene mutation in the enzyme responsible for homocysteine metabolism results in hyperhomocysteinemia.Nutritional deficiencies in B group vitamins(folic acid,VitB12,VitB6) can induce hyperhomocysteinemia.B group vitamins improve endothelial function by lowering serum levels of homocysteine. |
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| Keywords: | homocysteine endothelial dysfunction folic acid vitamin B12 vitamin B6 |
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