| 部分睡眠剥夺对大鼠免疫功能的影响 |
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| 引用本文： | 章茜,阎艳琴,乔鹏,袁义强,王书春,张朝,王雨若.部分睡眠剥夺对大鼠免疫功能的影响[J].郑州大学学报(医学版),2001,36(5):559-561. |
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| 作者姓名： | 章茜 阎艳琴 乔鹏 袁义强 王书春 张朝 王雨若 |
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| 作者单位： | 1. 河南医科大学生理学教研室,
2. 郑州市骨科医院内科, |
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| 基金项目： | 河南省教委科研基金资助 99310 0 0 5 |
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| 摘 要： | 目的 :探讨睡眠与免疫的关系。方法 :将SD大鼠 2 2只随机分为睡眠剥夺组和对照组各 11只 ,采用免疫学方法分别观察了脾细胞增殖反应 ,迟发型超敏反应的变化。结果 :由刀豆蛋白A ,脂多糖诱导的细胞增殖反应降低 ,脾细胞抗体分泌减少 ,迟发型超敏反应抑制 ,胸腺和脾脏质量降低。结论 :睡眠剥夺可抑制大鼠的免疫功能。
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| 关 键 词： | 睡眠 免疫 睡眠剥夺 大鼠 |
| 修稿时间： | 2000年10月12 |
Partial sleep deprivation impairs immune function in rats |
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| ZHANG Qian ,YAN Yanqin ,QIAO Peng ,YUAN Yiqiang ,WANG Shuchun ,ZHANG Zhao ,WANG Yuruo.Partial sleep deprivation impairs immune function in rats[J].Journal of Zhengzhou University: Med Sci,2001,36(5):559-561. |
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| Authors: | ZHANG Qian YAN Yanqin QIAO Peng YUAN Yiqiang WANG Shuchun ZHANG Zhao WANG Yuruo |
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| Institution: | ZHANG Qian 1),YAN Yanqin 2),QIAO Peng 1),YUAN Yiqiang 1),WANG Shuchun 1),ZHANG Zhao 1),WANG Yuruo 1) 1)Department of Physiology,Henan Medical University,Zhengzhou 450052 2)Zhengzhou Orthopaedics Hospital,Zhengzhou 4500 |
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| Abstract: | Aim: To explore the relationship between sleep and immune function.Methods:A total of 22 SD rats were divided into 2 groups of 11 each:sleep deprivation group and control group.The immunology methods were used to observe the changes of the proliferative reactivity of spleen cells and delayed hypersensitivity in rats undergoing partial sleep deprivation.Results:The data showed that spleen cell proliferation reaction induced by ConA or LPS obviously decreased and functions of spleen antibody secreting cells were obviously suppressed after sleep deprivation.Four d after sleep deprivation,delayed hypersensitivity was obviously suppressed.The thymuses and spleens of rats deprived sleep were atrophied,and the histology of immune organs had not changed.Conclusion:The study suggests that sleep deprivation can suppress the immune reactions |
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| Keywords: | sleep immune function sleep deprivation rat |
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