K-ras mutation in the major duodenal papilla and gastric and colonic mucosa in patients with autoimmune pancreatitis期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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K-ras mutation in the major duodenal papilla and gastric and colonic mucosa in patients with autoimmune pancreatitis

Authors:	Terumi Kamisawa Shin-Ichirou Horiguchi Yukiko Hayashi Xiaoqing Yun Toshikazu Yamaguchi Koji Tsuruta Tsuneo Sasaki

Institution:	(1) Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo 113-8677, Japan;(2) Department of Pathology, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan;(3) Division of Clinical Development of Biomedical Laboratories, Saitama, Japan;(4) Department of Surgery, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan;(5) Department of Chemotherapy, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan

Abstract:	Background Pancreatic cancer occurs in some patients with autoimmune pancreatitis (AIP). Significant K-ras mutations are frequently detected in the pancreas of AIP patients. AIP may be a pancreatic lesion of IgG4-related systemic disease. Gastric and colonic cancer can occur during the follow up of AIP patients. We examined K-ras mutations in the major duodenal papilla and gastric and colonic mucosa of AIP patients.

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