| 阿司匹林对急性脑梗死患者血浆NO及血小板α颗粒膜蛋白含量的影响 |
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| 引用本文： | 林爱琴,赵凤臣,倪居,邓双全. 阿司匹林对急性脑梗死患者血浆NO及血小板α颗粒膜蛋白含量的影响[J]. 郑州大学学报(医学版), 2005, 40(3): 517-519 |
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| 作者姓名： | 林爱琴 赵凤臣 倪居 邓双全 |
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| 作者单位： | 郑州大学基础医学院病理生理学教研室,郑州,450052;郑州铁路职业技术学院医学院内科教研室,郑州,450052;郑州铁路职业技术学院医学院内科教研室,郑州,450052 |
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| 摘 要： | 目的:探讨阿司匹林对急性脑梗死患者血浆一氧化氮(NO)及血小板α颗粒膜蛋白(GMP140)的影响。方法:83例急性脑梗死患者随机分为阿司匹林组(43例)和对照组(40例)。2组均给予常规治疗,阿司匹林组在此基础上服用阿司匹林150mg/d,治疗2周。治疗前后,分别采用硝酸酶还原法和双抗体夹心酶联免疫吸附法测定2组血浆NO及GMP140含量,并按照欧洲卒中评分(ESS)标准进行评分。结果:治疗后阿司匹林组血浆NO及GMP140含量均较对照组下降(P<0.01),但ESS分值变化2组间差异无统计学意义(P>0.05)。结论:阿司匹林能降低急性脑梗死患者血浆NO及GMP140的水平。
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| 关 键 词： | 脑梗死 阿司匹林 NO 血小板α颗粒膜蛋白 |
| 修稿时间： | 2005-01-11 |
Effect of aspirin on plasma NO and alpha-granule membrane protein in patients with acute cerebral infarction |
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| LIN Aiqin,ZHAO Fengchen,NI Ju,DENG Shuangquan. Effect of aspirin on plasma NO and alpha-granule membrane protein in patients with acute cerebral infarction[J]. Journal of Zhengzhou University: Med Sci, 2005, 40(3): 517-519 |
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| Authors: | LIN Aiqin ZHAO Fengchen NI Ju DENG Shuangquan |
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| Affiliation: | LIN Aiqin 1,2),ZHAO Fengchen 2),NI Ju 2),DENG Shuangquan 2) 1)Department of Pathophysiology,College of Basic Medical Sciences,Zhengzhou University,Zhengzhou 450052 2)Department of Medicine,Medical School,Zhengzhou Railway Professional Technology College,Zhengzhou 450052 |
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| Abstract: | Aim: To investigate the effect of aspirin on plasma levels of nitric oxide(NO) and alpha-granule membrane protein-140(GMP-140) in patients with acute cerebral infarction. Methods:A total of 83 cases of acute cerebral infarction were randomly divided into the aspirin group (43 cases) and the control group (40 cases). Plasma NO and GMP-140 were determined by using the method of nitrate reductase and enzyme-linked immunosorbent assay in aspirin group and control group at moment of hospitalization and after two weeks.Results: Plasma NO and GMP-140 of aspirin group after treatment were statistically lower than that of the control(P<0.01), but ESS of the 2 groups had no significant difference after treatment(P>0.05). Conclusion: Aspirin can reduce plasma NO and GMP-140 in patients with acute cerebral infarction,thus ameliorate brain injury after ischemia. |
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| Keywords: | cerebral infarction aspirin NO alpha-granule membrane protein |
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