A Case of Pneumocytoma (So-Called Sclerosing Hemangioma) With Lymph Node Metastasis |
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Authors: | TANAKA, ISAO INOUE, MASAHARU MATSUI, YASUO ORITSU, SATORU AKIYAMA, OSAMU TAKEMURA, TAMIKO FUJIWARA, MUTSUNORI KODAMA, TETSURO SHIMOSATO, YUKIO |
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Affiliation: | 1Departments of Thoracic Surgery, Japanese Red Cross Medical Center Tokyo 2Departments of Internal Medicine, Japanese Red Cross Medical Center Tokyo 3Departments of Pathology, Japanese Red Cross Medical Center Tokyo 4Pathology Division, National Cancer Center Research Institute Tokyo |
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Abstract: | A case of "sclerosing hemangionia" (pneumocytoma) of the lungwith lymph node metastasis is reported. A 22-year-old Japaneseman was found to have a well-defined round lesion in the rightlung (S7), which increased in size slightly during a 2-yearfollow-up period. He underwent right lower lobectomy with a preoperative diagnosisof a benign lung tumor. The pulmonary tumor revealed histologicalfeatures characteristic of "sclerosing hemangioma" of the lung,in addition to which there were many large polygonal foamy cells,forming tubular or papillary structures. These cells were foundby electron microscopy to contain numerous cytoplasmic lamellarbodies and showed a positive reaction with anti-surfactant apoproteinantibody immunohistochemically. Therefore, they were consideredto be cells differentiating toward type II pneumocytes. Reviewof 21 typical "sclerosing hemangionia" disclosed a few or somesuch foamy cells in 10 cases. A single hilar lymph node wasthe site of microscopic metastases, which consisted of "largeclear foamy cells" and smaller polygonal or round cells withslightly eosinophilic cytoplasm, both of which were componentsof the pulmonary "sclerosing hemangioma" This case supportsthe theory that "sclerosing hemangioma" is a neoplasm of typeII pneumocyte lineage. Although it is said to be benign, rarecases apparently show metastatic potential. |
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Keywords: | Sclerosing hemangioma Lung Pneumocytoma Surfactant apoprotein Metastasis |
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