S100 calgranulin proteins S100A8, S100A9 and S100A12 are expressed in the inflamed gastric mucosa of Helicobacter pylori-infected children. |
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| Authors: | Steven T Leach Hazel M Mitchell Carolyn L Geczy Philip M Sherman Andrew S Day |
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| Affiliation: | School of Women's and Children's Health, University of New South Wales, Sydney, Australia. s.leach@unsw.edu.au |
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| Abstract: | The expression of the inflammatory S100 calgranulin proteins (S100A8, S100A9 and S100A12) in normal and Helicobacter pylori-infected gastric mucosa of children were examined. S100A8, S100A9 and S100A12, which were virtually absent in normal gastric mucosa, were highly expressed in H pylori-infected mucosa. This expression correlated with the severity of gastritis (r=0.9422, P<0.05). S100 calgranulins may be involved in bacterial-induced gastritis and may limit bacterial growth. |
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