| Regulation of thenorphine on the CKK and CKK- BR gene expression in the different brain domains of rats |
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| 作者姓名： | Li Shu - hui Gong Ze - hui Xiao Wen - bin Li Jin Qin Bo - yi |
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| 作者单位： | Beijing Institute of Pharmacology and Toxicology, Beijing 100850 |
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| 摘 要： | Thenorphine is a new partial agonist of opioid receptors synthesized by our department. Our previous studies have found that thenorphine can antagonize the effects of morphine with a long time, suggesting a promising effect for the detoxification treatment. It is known that cholecystokinin （CKK） is one of the important antiopioid peptides that counter opioid effects. Furtherly, CCK appears to exert its anti-opioid actions mainly through the activation of CCK - B receptors.
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| 关 键 词： | 基因表达 缩胆囊素 缩胆囊素-BR 脑部损伤 小鼠 动物模型 |
Regulation of thenorphine on the CKK and CKK- BR gene expression in the different brain domains of rats |
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| Authors: | Li;Shu;-;hui;Gong;Ze;-;hui;Xiao;Wen;-;bin;Li;Jin;Qin;Bo;-;yi |
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| Abstract: | |
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| Keywords: | thenorphine CKK CKK- BR mRNA expression stratium thalamus hippocampus RT- PCR |
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