丙胺苯丙酮与硝酸异山梨酯对冠心病无症状心肌缺血伴室性期前收缩的治疗分析

目的:评价丙胺苯丙酮合用硝酸异山梨酯对冠心病无症状心肌缺血(Silentmyocardialischemia,SMI)伴室性期前收缩(Prematureventricularcontraction,PVC)的治疗效果。方法:将97例冠心病SMI伴PVC患者随机分为3组,其中A组32例口服丙胺苯丙酮与硝酸异山梨酯;B组33例口服硝酸异山梨酯加安慰剂;C组32例口服丙胺苯丙酮加安慰剂。前者作为治疗组,后两者作为对照组。评价内容含血压、心率、二重乘积、PVC改善情况及心电图ST段压低次数,ST段压低持续总时间,心肌缺血总负荷等。结果:97例中全部完成疗程。3组用药后上述观察指标差异均有不同程度改善,其中以治疗组最明显。治疗组与两对照组比较,心率、二重乘积、PVC差异均有统计学意义(P<0.01),且治疗组用药前后自身比较,上述指标也有统计学意义(P<0.01),SMI的发作次数及其持续总时间显著减少(P<0.01),心肌缺血总负荷也显著降低(P<0.01)。治疗组和对照组比较,血压影响差异无统计意义(P>0.05),未见明显不良反应。结论:丙胺苯丙酮与硝酸异山梨酯治疗SMI伴PVC有效。

The Curative Effect of Propylamine Benzene Acetone plus Isosorbid Dimitrate on Silent Myocardial Ischemia Combined with Premature Ventricular Contraction

Objective:To evaluate the curative effect of propylamine benzene acetone plus isosorbid dinitrate on silent myocardial ischemia(SMI)combined with premature ventricular contraction(PVC).Methods:97 cases of SMI combined with PVC were divided into 3 groups.Group A (treated group,)was given orally SMI plus PVC.Guoup B and group C control group I and II)took by mouth isosorbid dinitrate plus placebo and propylamine benzene acetone plus placebo,respectively.After that the blood pressure,heart rate,product of HR×SBP×10~(-2),diveloped degree of PVC,the drop times of ST section in electrocariogram,the duration of drop of ST section and total load of myocardial ischemia were evaluoted.Results: After medication the aforementioned indices were improved in varying degrees in three group especially in group A The difference in heart rate,product of HR×SBP×10~(-2) and PVC between group A and groups B,C were of statistical significance (P<0.01).In group A there was a remarkeble difference before and after medication (P<0.01)in the indices described above.The time of SMI atteck and its duration decreased obviously (P<0.01),and the total load of myocardial ischemia was markedly bronght down(P<0.01).There was little difference in influence of blood pressure between treated group and two control groups(P>0.05),and the patients in these groups did not show any untoward reactions.Conclusion:Propylamine benzene acetone plus isosorbid dinitrate can be used to treat effectively SMI combined with PVC.