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| 乙酰胆碱对海马CA1区痛兴奋神经元电活动的影响 | |
| 引用本文： | 肖宇,杨晓芳,徐满英.乙酰胆碱对海马CA1区痛兴奋神经元电活动的影响[J].齐齐哈尔医学院学报,2010,31(5):673-675. |
| 作者姓名： | 肖宇 杨晓芳 徐满英 |
| 作者单位： | 1. 齐齐哈尔医学院生理学教研室,161006 2. 复旦大学脑科学研究院 3. 哈尔滨医科大学生理学教研室 |
| 摘 要： | 目的 研究侧脑室注射乙酰胆碱(acetylcholine,Ach)对大鼠海马 CA1 区痛兴奋神经元(pain-excitation neurons, PEN)电活动的影响.方法 以电脉冲刺激右侧坐骨神经作为伤害性刺激,用玻璃微电极细胞外记录神经元放电.结果 1) 伤害性刺激使海马 CA1 区 PEN 诱发放电频率增加; 2)与对照组相比,脑室注射 Ach (20μg/10μl)后PEN诱发放电频率的净增值减少,潜伏期延长(P<0.05).结论 Ach 参与了海马CA1区伤害性信息的调制. |
| 关 键 词： | 乙酰胆碱 海马CA1区 痛兴奋神经元 电活动 |
Effect of acetylcholine on the electric discharge of pain-excitation neurons in hippocampal CA1 area |
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| XIAO Yu,et al..Effect of acetylcholine on the electric discharge of pain-excitation neurons in hippocampal CA1 area[J].Journal of Qiqihar Medical College,2010,31(5):673-675. | |
| Authors: | XIAO Yu |
| Institution: | XIAO Yu,et al.(Department of Physiology,Qiqihar Medical University,Qiqihar,Heilongjiang 161006,P.R.China) |
| Abstract: | Objective To study the effect of intracerebroventricular(icv) injection acetylcholine(ACh) on the electric activities of pain-excitation neurons(PEN) in the hippocampal CA1 area of rat. Methods Trains of the electric impulses applied to the right sciatic nerve were used as noxious stimuli,the discharges of neurons were led out by extracellular recording method with glass microelectrodes.Results 1) Noxious stimulation enhanced the frenquency of evoked discharge of PEN;2) Contrast to the normal group,icv inje... |
| Keywords: | Acetylcholine Hippocampal CA1 area Pain-excited neurons Electric activity |
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