高频彩超结合血管内皮因子C对乳腺癌腋窝淋巴结转移的诊断价值

目的探讨彩色多普勒超声(CDFI)结合血管内皮生长因子C(VEGF-C)对浸润性乳腺癌腋窝淋巴结转移的诊断价值。方法应用免疫组化技术VEGF-C结合CDFI声像图特点对59例浸润性乳腺癌患者腋窝淋巴结状态进行比较研究。结果乳腺癌腋窝淋巴结转移组较未转移组肿瘤内彩色血流信号丰富(P<0.05);>2cm组较≤2cm组肿瘤内彩色血流信号丰富(P<0.05)。淋巴结转移组较未转移组VEGF-C阳性表达率明显增高(P<0.05)。结论浸润性乳腺癌CDFI肿瘤内彩色血流信号丰富程度及VEGF-C阳性表达率与腋窝淋巴结发生转移密切相关。

Value of Ultrasonography Combined with Vascular endothelial growth factor C to Evaluate the Diagnosis of Axillary Lymph Node Metastasis in Patients with Breast Carcinoma

Objective Breast cancer specimens were ana lyzed with immunohistochemical VEGF-C combined with CDFI to evaluate axillary l ymph node(LN) metastasis. Methods Fifty nine women with primary breast cancer were studie d with CDFI.After surgery the axillary LN metastases were analyzed with VEGF-C experiment. Results The color blood flow signals in the tumors with axi llary LN metastasis were higher than those without metastasis(P<0.05).T he blood flow signals in the tumors larger than 2 cm were higher than those less than 2 cm(P<0.05).The VEGF-C were higher in the tumors with metastasi s than those without metastasis(P<0.05).Conclusions CD FI combined with VEGF-C may identify breast cancer with LN metastasis from thos e without metastasis.