| 脑源性神经营养因子:治疗阿尔采末病的新策略 |
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| 引用本文： | 龚其海,李菲,黄彬,石京山.脑源性神经营养因子:治疗阿尔采末病的新策略[J].中国新药与临床杂志,2011(4). |
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| 作者姓名： | 龚其海 李菲 黄彬 石京山 |
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| 作者单位： | 遵义医学院药理学教研室;遵义医学院贵州省基础药理重点实验室; |
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| 基金项目： | 国家自然科学基金(81060349); 贵州省教育厅自然科学重点项目(2009111) |
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| 摘 要： | 阿尔采末病(又名阿尔茨海默病)的病因及发病机制复杂不清,目前脑源性神经营养因子在其发生、发展过程中的作用日益受到关注。本文综述了脑源性神经营养因子的生物学特点及作用,特别强调了脑源性神经营养因子在阿尔采术病病理生理学过程中的作用,旨在为后续研究该病的治疗药物提供新策略。
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| 关 键 词： | 阿尔茨海默病 脑源性神经营养因子 酪氨酸激酶受体B 学习 记忆 |
Brain-derived neurotrophic factor:a new strategy for Alzheimer disease therapy |
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| GONG Qi-hai,LI Feia,HUANG Bina,SHI Jing-shan.Brain-derived neurotrophic factor:a new strategy for Alzheimer disease therapy[J].Chinese Journal of New Drugs and Clinical Remedies,2011(4). |
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| Authors: | GONG Qi-hai LI Feia HUANG Bina SHI Jing-shan |
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| Institution: | GONG Qi-hai~(a,b),LI Fei~a,HUANG Bin~a,SHI Jing-shan~(a,b) (a.Department of Pharmacology,b.The Key Laboratory of Basic Pharmacology of Guizhou Province,Zunyi Medical College,Zunyi GUIZHOU 563000,China) |
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| Abstract: | The etiology and pathogenesis of Alzheimer disease(AD) are complicated and unclear,and the effects of brain-derived neurotrophic factor(BDNF) in AD are payed more and more attention.This review sum-marizes biological characters and actions of BDNF,especially highlights the actions of BDNF on AD pathophysiology,in order to provide a new strategy for subsequent AD therapy. |
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| Keywords: | Alzheimer disease brain-derived neurotrophic factor tyrosine kinase receptors B learning memory |
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