nobiliside A隐形纳米脂质体对小鼠RM-1前列腺癌的抑制作用

目的比较nobiliside A隐形纳米脂质体(NASNL)和nobiliside A普通脂质体(NACL)对小鼠RM-1前列腺癌的抑制作用。方法 RM-1前列腺癌荷瘤小鼠随机分为6组(均n=10):阴性对照组(生理盐水)、阳性对照组(环磷酰胺20 mg·kg~(-1)·d~(-1))、NACL低、高剂量组(1 mg·kg~(-1)·d~(-1)、2 mg·kg~(-1)·d~(-1))和NASNL低、高剂量组(1 mg·kg~(-1)·d~(-1)、2 mg·kg~(-1)·d~(-1)),均尾静脉注射给予相应药物,连续7 d。通过比较各组小鼠的肿瘤生长曲线、抑瘤率、肿瘤组织的病理变化等考察2种脂质体的抑瘤效果。结果 NASNL两剂量组的肿瘤生长速度均低于相应剂量的NACL组(P<0.05)。NASNL两剂量组的抑瘤率均高于相应的NACL组,其中NASNL高剂量组的抑瘤率是NACL高剂量组的2倍。NASNL各组肿瘤细胞坏死程度高于NACL各组。结论 NASNL的肿瘤抑制作用明显优于NACL。

Antitumor effects of nobiliside A stealth nano-liposome on RM-1 prostate cancer in mice

AIM To compare the antitumor effects of nobiliside A stealth nano-liposomes(NASNL)and nobiliside A conventional liposomes(NACL)on RM-1 prostate cancer in C57BL6/J mice.METHODS Mouse models were made by subcutaneously injection of RM-1 prostate cancer cells.Sixty mice were randomized into 6 groups(n=10 for each group)and were treated with intravenous injection of normal saline,cyclophosphamide (20 mg·kg~(-1)·d~(-1)),NACL(1g·kg~(-1)·d~(-1),2 mg·kg~(-1)·d~(-1))or NASNL(1 mg·kg~(-1)·d~(-1),2 mg·kg~(-1)·d~(-1))for 7 days,respectively.The tumor volume and weight were measured after the treatment,and the pathological changes were also observed.RESULTS Tumor growth rates of the NASNL groups were slower than those of the NACL groups(P<0.05).The tumor inhibition rates of the NASNL groups were higher than those of the NACL groups(P<0.05).The pathological changes showed that tumor necrosis was significantly greater in the NASNL groups than that in the NACL groups.CONCLUSION NASNL is more effective in suppressing tumor growth than NACL.