| 糖化血清白蛋白在2型糖尿病患者中的临床应用 |
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| 引用本文： | 李青,包玉倩,潘洁敏,屠印芳,张磊,张锋,周健,李鸣,于浩泳,贾伟平.糖化血清白蛋白在2型糖尿病患者中的临床应用[J].中国新药与临床杂志,2011(6). |
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| 作者姓名： | 李青 包玉倩 潘洁敏 屠印芳 张磊 张锋 周健 李鸣 于浩泳 贾伟平 |
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| 作者单位： | 上海交通大学附属第六人民医院内分泌代谢科上海市糖尿病临床医学中心上海市糖尿病重点实验室上海市糖尿病研究所; |
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| 基金项目： | 上海市市级医院新兴前沿技术联合攻关项目(SHDC12010115) |
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| 摘 要： | 目的分析2型糖尿病患者糖化血清白蛋白(GA)与各常用血糖参数的相关性及GA的影响因素,评价GA与糖尿病微血管并发症的相关性。方法 2007年5月—2009年10月我院2型糖尿病住院患者1 597例。患者入院初测定空腹静脉血糖(FPG)、餐后2 h血糖(2hPG)、GA、糖化血红蛋白(HbA_(lc))、24 h尿白蛋白定量,并行连续血糖监测(CGMS),全部患者均由眼科医生眼底摄片。结果 2型糖尿病患者入院时GA值为(25.8±7.8)%,HbA_(lc)为(9.0±2.3)%。GA与HbA_(lc)、FPG、2hPG、CGMS血糖均值均正相关(r=0.788、0.396、0.406、0.470,均P<0.01)。体重指数、2hPG、CGMS血糖均值是影响GA的主要因素。GA>17%组患者糖尿病视网膜病变的检出率高于GA≤17%组(P<0.01),GA>17%组患者糖尿病肾病的检出率与GA≤17%组间无显著差异(P>0.05)。结论 GA是一个可准确反映短期内平均血糖水平及变化的优良且检测方便的指标,GA与糖尿病视网膜病变的发生相关。
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| 关 键 词： | 糖尿病 2型 糖化血清白蛋白 血红蛋白A 糖基化 |
Clinical utility of glycated albumin in type 2 diabetic patients |
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| LI Qing,BAO Yu-qian,PAN Jie-min,TU Yin-fang,ZHANG Lei,ZHANG Feng,ZHOU Jian,LI Ming,YU Hao-yong,JIA Wei-ping.Clinical utility of glycated albumin in type 2 diabetic patients[J].Chinese Journal of New Drugs and Clinical Remedies,2011(6). |
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| Authors: | LI Qing BAO Yu-qian PAN Jie-min TU Yin-fang ZHANG Lei ZHANG Feng ZHOU Jian LI Ming YU Hao-yong JIA Wei-ping |
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| Institution: | LI Qing,BAO Yu-qian,PAN Jie-min,TU Yin-fang,ZHANG Lei,ZHANG Feng,ZHOU Jian,LI Ming,YU Hao-yong,JIA Wei-ping (Department of Endocrinology and Metabolism,Shanghai Jiaotong University Affiliated Sixth People's Hospital,Shanghai Clinical Center for Diabetes,Shanghai Key Laboratory of Diabetes Mellitus,Shanghai Diabetes Institute,SHANGHAI 200233,China) |
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| Abstract: | AIM To analyze the correlation of glycated albumin(GA)with glycemic indices and influential factors of GA,and to evaluate the association of GA and diabetic microvascular complications. METHODS A total of 1597 type 2 diabetic patients hospitalized from May 2007 to October 2009 in our department were enrolled in this study.Fasting plasma glucose(FPG),2 h postprandial plasma glucose(2hPG), GA,glycosylated hemoglobin A_(1c)(HbA_(1c))and 24 hour urinary albumin were measured,and continuous glucose monitoring sy... |
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| Keywords: | diabetes mellitus type 2 glycated albumin hemoglobin A glycosylated |
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