| 2型糖尿病患者血清甲状腺素与血脂水平的相关性 |
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| 引用本文： | 潘洁敏,张磊,包玉倩,陆汉魁,贾伟平.2型糖尿病患者血清甲状腺素与血脂水平的相关性[J].中国新药与临床杂志,2011(6). |
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| 作者姓名： | 潘洁敏 张磊 包玉倩 陆汉魁 贾伟平 |
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| 作者单位： | 上海交通大学附属第六人民医院内分泌代谢科上海市糖尿病临床医学中心上海市糖尿病重点实验室上海市糖尿病研究所; |
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| 摘 要： | 目的探讨2型糖尿病患者甲状腺素水平与血脂代谢之间的相关性。方法 2型糖尿病住院患者478例,年龄20～87岁,记录血压、体重指数,入院d 2空腹测定总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、糖化血红蛋白(HbA_(lc)),游离三碘甲状腺原氨酸(FT_3)、游离甲状腺素(FT_4)及促甲状腺素(TSH)水平。并根据患者甲状腺功能、TSH水平进行分组,分析不同甲状腺功能状态患者的血脂水平、TC和LDL-C的影响因素等。结果研究队列中,甲状腺功能减退症(甲减)110例(23.0%),亚临床甲状腺功能减退症(亚甲减)168例(35.2%)。女性患者的年龄低于男性(P<0.05),FT_4、TC和HDL-C水平高于男性(P<0.05)。甲减和亚甲减患者的TC和LDL-C水平显著高于甲状腺功能正常者(P<0.01),而在甲减和亚甲减患者间无显著差异(P>0.05)。TC和LDL-C随着TSH水平升高而进行性升高。TC及LDL-C均和FT_3负相关(r=-0.134、-0.1 12,P<0.05),和TSH正相关(r=0.195、0.247,P<0.05),和HbA_(lc)正相关(r=0.298、0.308,P<0.01)。HbA_(lc)、FT_3、TSH和LDL-C是影响TC变化的独立因素,FT_3、TSH和TC是影响LDL-C变化的独立因素。结论 2型糖尿病患者FT_3和TSH水平是独立于血糖控制情况,影响TC及LDL-C水平的因素。
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| 关 键 词： | 糖尿病 2型 甲状腺功能减退症 胆固醇 胆固醇 LDL |
Correlation between serum thyroid hormones and lipid profile in type 2 diabetes mellitus patients |
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| PAN Jie-min,ZHANG Lei,BAO Yu-qian,LU Han-kui,JIA Wei-ping.Correlation between serum thyroid hormones and lipid profile in type 2 diabetes mellitus patients[J].Chinese Journal of New Drugs and Clinical Remedies,2011(6). |
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| Authors: | PAN Jie-min ZHANG Lei BAO Yu-qian LU Han-kui JIA Wei-ping |
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| Institution: | PAN Jie-min,ZHANG Lei,BAO Yu-qian,LU Han-kui,JIA Wei-ping (Department of Endocrinology and Metabolism,Shanghai Jiaotong University Affiliated Sixth People's Hospital,Shanghai Clinical Center for Diabetes,Shanghai Key Laboratory of Diabetes Mellitus,Shanghai Diabetes Institute,SHANGHAI 200233,China) |
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| Abstract: | AIM To evaluate the correlation between serum thyroid hormones and lipid profile in type 2 diabetes mellitus patients.METHODS A total of 478 diabetic patients aged from 20 to 87 years and hospitalized from January 2008 to October 2009,were enrolled in this study.The blood pressure and body mass index were recorded.The total cholesterol(TC),triglycerides,high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),glycosylated hemoglobin A_(1c)(HbA_(1c)),free tri-iodothyronine(FT_3)... |
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| Keywords: | diabetes mellitus type 2 hypothyroidism cholesterol LDL |
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