| 血卟啉衍生物对X线增敏作用的生化研究 |
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| 引用本文： | 徐惠英,夏寿萱,范国才. 血卟啉衍生物对X线增敏作用的生化研究[J]. 军事医学科学院院刊, 1987, 0(5) |
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| 作者姓名： | 徐惠英 夏寿萱 范国才 |
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| 作者单位： | 军事医学科学院放射医学研究所(徐惠英，夏寿萱)，军事医学科学院放射医学研究所(范国才) |
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| 摘 要： | 通过对小鼠S-180腹水瘤细胞DNA单链断裂及其重接的测定和细胞质膜对~(50)CrO_4~(2-)通透性的测定,探讨了光敏剂血卟啉衍生物(HPD)是否对X线增敏的问题。结果表明,在避光时HPD对X线的增敏作用不明显,但在自然光的照射下,HPD能增强X线的辐射效应,表现在DNA单链断裂重接的抑制和膜通透性的加强。对上述现象的原因进行了讨论。
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| 关 键 词： | 血卟啉 辐射增敏作用 DNA损伤和修复 细胞膜 |
BIOCHEMICAL STUDY OF THE SENSITIZATION EFFECT OF HEMATOPORPHYRIN DERIVATIVES ON X-RAY IRRADIATION |
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| Xu Huiying Xia Shouxuan Fan Guocai. BIOCHEMICAL STUDY OF THE SENSITIZATION EFFECT OF HEMATOPORPHYRIN DERIVATIVES ON X-RAY IRRADIATION[J]. Bulletin of the Academy of Military Medical Sciences, 1987, 0(5) |
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| Authors: | Xu Huiying Xia Shouxuan Fan Guocai |
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| Abstract: | By the estimation of the single strand breaks (SSB) of DNA and their rejoining and by the measurement of the changes in cell membrane permeability, the sensitization effect of hematoporphyrin derivatives (HPD) on X-ray irradiation in S-180 tumor cells was studied. It was found that if the exposure to natural light was prevented during the experiments, no radiosensitization effect of HPD was observed; but under the natural light HPD would enhance the effect of X-ray irradiation, resulting in the irreversible inhibition of DNA SSB rejoining and increase of membrane permeability. This phenomenon was tentatively interpreted. |
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| Keywords: | hematoporphyrin radiosensitization DNA damage and repair cell membrane |
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