中枢胆碱能神经系统功能的研究进展

中枢胆碱能神经系统是中枢胆碱能神经元及其纤维投射分布的部位 ,与学习、记忆等高级神经活动密切相关。围产期缺氧缺血脑损伤及大脑的退行性改变常引起中枢胆碱能神经系统受损并导致学习和记忆等高级神经功能障碍 ,成为老年痴呆等疾病的重要发病机制之一。中枢胆碱能神经系统与神经营养因子和一些胆碱酯酶抑制剂之间有着密切的关系 ,具有许多新的功能。

Recent Progress in Research on Functions of the Central Cholinergic Neuronal System

The central cholinergic neuronal system is the domain of cholinergic neurons distribution and their fibres projection, which is closely related to higher nervous activities, such as learning and memory. Perinatal hypoxic-ischemic brain damage and cerebral degeneration often result in impairment of the central cholinergic neuronal system and dysfunction of learning and memory, which become one of the important pathogenses in Alzheimer's disease. The central cholinergic neuronal system is closely associated with neurotrophic factors and some acetylcholinesterase inhibitors, and they also have some novel functions.