Advanced airway management in out of hospital cardiac arrest: A systematic review and meta-analysis |
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Authors: | Leigh White Thomas Melhuish Rhys Holyoak Thomas Ryan Hannah Kempton Ruan Vlok |
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Affiliation: | 1. School of Medicine, University of Queensland, Brisbane, QLD, Australia;2. Department of Anaesthesia and Perioperative Medicine, Sunshine Coast University Hospital, Sunshine Coast, QLD, Australia;3. Intensive Care Service, Royal Prince Alfred Hospital, Sydney, NSW, Australia;4. Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia;5. Graduate School of Medicine, University of Wollongong, Wollongong, NSW, Australia;6. Department of Orthopaedics, John Hunter Hospital, Newcastle, NSW, Australia;7. Sydney Clinical School, University of Notre Dame, Sydney, NSW, Australia;8. Department of Medicine, St Vincent''s Hospital, Sydney, NSW, Australia;9. Wagga Wagga Rural Referral Hospital, Wagga Wagga, NSW, Australia |
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Abstract: | ObjectivesTo assess the difference in survival and neurological outcomes between endotracheal tube (ETT) intubation and supraglottic airway (SGA) devices used during out-of-hospital cardiac arrest (OHCA).MethodsA systematic search of five databases was performed by two independent reviewers until September 2018. Included studies reported on (1) OHCA or cardiopulmonary resuscitation, and (2) endotracheal intubation versus supraglottic airway device intubation. Exclusion criteria (1) stimulation studies, (2) selectively included/excluded patients, (3) in-hospital cardiac arrest. Odds Ratios (OR) with random effect modelling was used. Primary outcomes: (1) return of spontaneous circulation (ROSC), (2) survival to hospital admission, (3) survival to hospital discharge, (4) discharge with a neurologically intact state.ResultsTwenty-nine studies (n?=?539,146) showed that overall, ETT use resulted in a heterogeneous, but significant increase in ROSC (OR?=?1.44; 95%CI?=?1.27 to 1.63; I2?=?91%; p?0.00001) and survival to admission (OR?=?1.36; 95%CI?=?1.12 to 1.66; I2?=?91%; p?=?0.002). There was no significant difference in survival to discharge or neurological outcome (p?>?0.0125). On sensitivity analysis of RCTs, there was no significant difference in ROSC, survival to admission, survival to discharge or neurological outcome (p?>?0.0125). On analysis of automated chest compression, without heterogeneity, ETT provided a significant increase in ROSC (OR?=?1.55; 95%CI?=?1.20 to 2.00; I2?=?0%; p?=?0.0009) and survival to admission (OR?=?2.16; 95%CI?=?1.54 to 3.02; I2?=?0%; p?0.00001).ConclusionsThe overall heterogeneous benefit in survival with ETT was not replicated in the low risk RCTs, with no significant difference in survival or neurological outcome. In the presence of automated chest compressions, ETT intubation may result in survival benefits. |
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Keywords: | Cardiac arrest Intubation Advanced airway management Laryngeal mask Laryngeal tube |
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