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| 血管内皮生长因子表达与食管鳞癌临床病理的关系 | |
| 引用本文： | 李健,袁天柱,周琦,王立东. 血管内皮生长因子表达与食管鳞癌临床病理的关系[J]. 临床内科杂志, 2001, 18(1): 39-41 |
| 作者姓名： | 李健 袁天柱 周琦 王立东 |
| 作者单位： | 1. 河南医科大学第二附属医院消化内科 2. 河南医科大学第二附属医院 3. 河南医科大学癌症研究室 |
| 基金项目： | 国家自然科学基金!资助课题 (39840 0 1 2 ) |
| 摘 要： | 目的 了解食管鳞癌组织中血管内皮生长因子（VEGF）的变化及其与临床病理的关系。方法 采用ABC方法测定食管鳞癌高发区74例食管鳞癌组织中VEGF蛋白的表达。结果 74例食管鳞癌组织中VEGF阳性表达为60.8%（45/74例），VEGF阳性表达与食管鳞癌组织中肿瘤细胞增殖、浸润和淋巴结转移有相关性。VEGF在食管鳞癌中的表达存在有异质性。结论 VEGF蛋白在食管鳞癌的增殖、浸润和转移过程中起重要作用。 |
| 关 键 词： | 食管磷癌 病理学 血管内皮生长因子 免疫组织化学 |
| 文章编号： | 1001-9057(2001)01-0039-03 |
| 修稿时间： | 2000-02-21 |
Relationship between expression of vascular endothelial growth factor and clinicopathologic characteristics in esophageal squamous carcinoma |
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| LI Jian,YUAN Tianzhu,ZHOU Qi,et al.. Relationship between expression of vascular endothelial growth factor and clinicopathologic characteristics in esophageal squamous carcinoma[J]. Journal of Clinical Internal Medicine, 2001, 18(1): 39-41 | |
| Authors: | LI Jian YUAN Tianzhu ZHOU Qi et al. |
| Affiliation: | LI Jian,YUAN Tianzhu,ZHOU Qi,et al.Department of Gastroenterology,the 2nd Affiliated Hospital of Henan Medical University,Zhengzhou 450003,China |
| Abstract: | Objective To evaluate the relationship between the vascular endothelial growth factor (VEGF) and the clinicopathologic characteristics in esophageal squamous carcinoma.Methods The expression of VEGF was determined in 74 esophageal squamous carcinoma samples in high-incidenced location by avidin-biotin-peroxidase complex(ABC) method.Results The positive rate of VEGF protein expression was 60.8％(45/74)，the immunostaining of VEGF protein showed significant relationship existed between positive expression of VEGF protein and proliferation，infiltration,metastasis of lymphaden(P<0.05).The heterogeneity of VEGF protein expression in esophageal squamous carcinoma was observed.Conclusions Expression of VEGF protein play a significant role in proliferation，infiltration and metastasis in esophageal squamous carcinoma. |
| Keywords: | Esophageal squamous carcinoma/pathology Vascular endothelial growth factor Immunohistochemistr |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |