| 2—氯代—3—甲基—4—三氟乙氧基吡啶N—氧化物的合成 |
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| 引用本文： | 刘鹰翔.2—氯代—3—甲基—4—三氟乙氧基吡啶N—氧化物的合成[J].广东药学院学报,1998,14(3):161-163. |
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| 作者姓名： | 刘鹰翔 |
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| 作者单位： | 广东药学院药物化学教研室 |
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| 摘 要： | 采用３－甲基吡啶作为起始原料，经氨基化，羟基化，氯代，Ｎ－氧化，硝化，氟化六步反应制备得到标题化合物２－氯代－３－甲基－４－三氟乙基吡啶Ｎ－氧化物。按（２）计算总收率为３．５％，其化学结构经元素分析，红外光谱和核心磁共振氢谱证实。
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| 关 键 词： | 取代吡啶 N－氧化物 化学合成 3－甲基吡啶 |
Synthesis of 2 Chloro 3 Methyl 4 (2,2,2 Trifluoro) ethoxypyridine N Oxide |
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| Liu Yingxiang,Ma Yuzhuo.Synthesis of 2 Chloro 3 Methyl 4 (2,2,2 Trifluoro) ethoxypyridine N Oxide[J].Academic Journal of Guangdong College of Pharmacy,1998,14(3):161-163. |
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| Authors: | Liu Yingxiang Ma Yuzhuo |
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| Abstract: | The title compound 2 chloro 3 methyl 4 (2,2,2 trifluoroethoxy) pyridine N oxide (1)was synthesized by six steps of aminoation, hydroxyration, chloroation, N oxidation, nitroation and fluroation with 3 picoline (2) as starting material. The overall yield was 3 5% The chemical structure of the compound (1) was determinated by elemental analysis,IR and 1H NMR spectra |
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| Keywords: | substituted pyridine N oxides chemical synthesis |
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