儿童肝损害病因及临床分析

目的：探析儿童肝损害的病因、临床表现、治疗方法及效果。方法：回顾性分析笔者所在医院2010年1月-2011年12月46例儿童肝损害的相关临床资料。结果：本组患儿肝损害的病因为：感染31例（67.4%）,药物损害13例（28.3%）,先天性遗传代谢性疾病2例（4.3%）。本组患儿的肝功能异常症状为：ALT增高至正常2倍8例（17.4%）,3~10倍29例（63.0%）;白蛋白〈35g/L为15例（32.6%）,总胆红素增高至正常2倍以上16例（34.8%）。经过0.5~2个月的治疗,肝功能恢复正常43例（93.5%）,因病情加重转送上级医院进行诊治3例（6.5%）。结论：儿童肝损害的主要病因为感染与药物,为了促进患儿的早期恢复,应做到及时发现与对症治疗。

Etiological and Clinical Analysis of Liver Damage in Children

Objective：Analysis of the etiology of hepatic damage in children,clinical manifestation, treatment methods and effects.Method：A retrospective analysis of our hospital from January 2010 to December 2011 in 46 cases of children with liver damage of relevant clinical information.Result：In this group of patients because of liver damage disease：infection in 31 cases （67.4%）,drug damage in 13 cases （28.3%）,congenital metabolic diseases in 2 cases （4.3%）.In this group of patients with abnormal liver function symptoms as：ALT increased to 2 times normal in 8 cases （17.4%）,3-10 times in 29 cases （63.0%）;albumin35 g/L in 15 cases （32.6%）,the total bilirubin increased to normal more than 2 times in 16 patients （34.8%）.After half a month to 2 months of treatment,liver function returned to normal in 43 cases （93.5%）,because of exacerbations to superior hospital for diagnosis and treatment of 3 cases （6.5%）.Conclusion：Hepatic damage in children’s main disease because of infection and drug,in order to promote children’s early recovery,should be timely found and symptomatic treatment.