| 葡多酚对高脂膳大鼠血浆α颗粒膜蛋白140和血栓素B_2的影响 |
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| 引用本文： | 杜惠琴 钟进义. 葡多酚对高脂膳大鼠血浆α颗粒膜蛋白140和血栓素B_2的影响[J]. 营养学报, 2005, 27(5): 428-430 |
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| 作者姓名： | 杜惠琴 钟进义 |
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| 作者单位： | 青岛大学医学院营养研究所 青岛266021(杜惠琴)，青岛大学医学院营养研究所 青岛266021(钟进义) |
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| 基金项目： | 山东省教育厅项目(No.03K01) |
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| 摘 要： | 目的:观察葡多酚(GPC)对大鼠血浆α颗粒膜蛋白140(GMP140)和血栓素B2(TXB2)的影响。方法:将饲以高脂饲料的大鼠每日经口灌胃给予不同剂量的GPC,连续6w,用放射免疫法检测血浆GMP140、TXB2及血脂水平。结果:高剂量GPC组大鼠血浆GMP140和TXB2含量分别为7.89±1.02ng/ml和131.71±42.13pg/ml,均低于高脂对照组,差别有显著性意义(P<0.05)。结论:葡多酚对高脂膳诱发大鼠血浆GMP140、TXB2的升高有抑制作用。
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| 关 键 词： | 葡多酚 α颗粒膜蛋白140(GMP140) 血栓素(TXB_2) |
| 文章编号： | 0512-7955(2005)-05-0428-03 |
| 收稿时间： | 2005-02-20 |
| 修稿时间： | 2005-02-20 |
EFFECT OF GRAPE PROCYANIDIN ON PLASMA GMP140 AND TXB2 IN RATS FED WITH HIGH FAT DIET |
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| DU Hui-qin,ZHONG Jin-yi. EFFECT OF GRAPE PROCYANIDIN ON PLASMA GMP140 AND TXB2 IN RATS FED WITH HIGH FAT DIET[J]. Acta Nutrimenta Sinica, 2005, 27(5): 428-430 |
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| Authors: | DU Hui-qin ZHONG Jin-yi |
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| Abstract: | Objective:To study the effect of grape procyanidin (GPC) on the levels of plasmaα-granule membrance protein 140 (GMP140) and thromboxane B2 (TXB2 ) in rats. Method:Wistar rats fed by high fat diet (HFD) were given GPC i.g. at different doses for 6 w, and the levels of plasma GMP140 and TXB2 were examined by radioimmunoassay (RIA). Result:Plasma GMP140 and TXB2 levels of high dose GPC were respectively 7.89±1.02ng/ml, 131.71±42.13 pg/ml, significantly lower than those of HFD group. Conclusion:GPC could inhibit the increase of plasma GMP140 and TXB2 induced by high fat diet in rats. |
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| Keywords: | GPC GMP140 TXB2 |
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