肾移植术后上尿路梗阻14例临床诊治体会

目的探讨肾移植术后上尿路梗阻的诊断及处理。方法回顾总结2000—2006年我院1090例肾移植患者中的14例移植后上尿路梗阻患者，其中输尿管膀胱吻合口狭窄9例，6例行膀胱输尿管二次吻合手术，1例移植肾周感染输尿管末段坏死采用移植肾近端新鲜存活输尿管与自体输尿管吻合，1例采用膀胱肌瓣代移植输尿管，1例采用输尿管镜下气囊扩张后放置双J管。出血相关性梗阻、输尿管扭曲和输尿管结石所致梗阻5例，均行开放手术。结果14例肾移植术后上尿路梗阻患者中2例切除移植肾，其余各例患者经开放手术及腔镜处理均成功挽救移植肾功能。再次手术后随访0．5—1年，血肌酐68-155μmol／L，B超未见移植肾扩张积水加重。结论新上尿路梗阻是肾移植术后常见亦是较为棘手的外科并发症，多数和外科手术操作有关，可以通过提高手术技巧避免。一旦发生上尿路梗阻，应根据梗阻原因采取相应的治疗方法及时处理。

Diagnosis and management of 14 cases of urinary obstruction following renal transplantation

Objective To explore the diagnosis and treatment of urinary obstruction following the transplanted kidney. Methods A retrospective analysis was performed in 14 cases of urinary obstruction among 1 090 cases of transplanted kidney in the year 2000-2006, including 9 cases of vesicoureteral anastomotic stricture, 6 of whom received a second vesicoureteral anastomosis, one had infection surrounding the renal graft and ureter end necrosis, two ureteral anastomosis with bladder muscle flap, and one stenostomia aerocyst distention under ureteroscope. Five patients with bleeding-related obstruction, ureter twist and ureteral calculus received operations. Results Two patients had the renal graft removed due to severe pyeloureteral hemorrhage, and the renal function of the graft was preserved in all the other cases after endoscopic or open surgeries. In the follow-up for 0.5 to 1 years after the second surgery, serum creatinine of the patients was maintained within the range of 68- 166 μmol/L, without further renal enlargement or exacerbation of renal retention shown by B-mode ultrasonography. Conclusion Upper urinary obstruction after renal transplantation is a difficult surgical complication, which can be managed by endoscopic or open surgeries depending on the causes of the obstruction.