The birthdates of GABA-immunoreactive amacrine cells in the rat retina |
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Authors: | M.-Y. Lee S.-L. Shin S.-H. Han M.-H. Chun |
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Affiliation: | (1) Department of Anatomy, College of Medicine, The Catholic University of Korea, Banpo-dong, Socho-gu, Seoul 137-701, Korea, e-mail: mhchun@cmc.cuk.ac.kr, Tel.: 82-2-590-1152, Fax: 82-2-536-3110, KR |
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Abstract: | The birthdates of GABAergic amacrine cells in the rat retina were investigated by immunocytochemistry using anti-GABA and anti-bromodeoxyuridine (BrdU) antisera. The ratio of co-localization of GABA to BrdU increased gradually from embryonic-day 13 (E13) and showed a peak value on E18 in the central retina and on E20 in the periphery. After birth, until postnatal-day 3 (P3), a few co-localized cells were observed in the inner nuclear layer (INL). However, in the peripheral retina, co-localized cells were observed in the INL and ganglion cell layer until P5. Our results suggest that the birthdates of GABA-immunoreactive cells vary, depending on cell-type and that there is a temporal lag in the GABA-immunoreactive cell production in the peripheral retina relative to the central retina. Received: 11 January 1999 / Accepted: 20 April 1999 |
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Keywords: | GABA Bromodeoxyuridine Proliferation Immunohistochemistry Retina Rat |
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