局部消融术联合细胞因子诱导的杀伤细胞治疗肝转移瘤临床效果观察

目的 观察局部射频消融(RFA)联合细胞因子诱导的杀伤(CIK)细胞疗法治疗肝转移瘤的临床疗效. 方法 50例肝转移瘤患者分为RFA联合自体CIK细胞治疗23例(研究组)和单纯RFA治疗27例(对照组).于治疗前后检测血清肿瘤标志物水平及CD3+、CD4+、CD8+、CD4+/CD8+,局部复发率和Kamofsky评分变化. 结果 联合治疗组局部复发率(13.04%)明显低于对照组(40.74%)(P<0.05);CD3+、CD4+、CIM+/CD8+均明显升高(P<0.01);肿瘤标志物下降者和Kamofsky评分升高者的比例均明显高于对照组(P<0.05). 结论 RFA联合CIK细胞治疗肝转移瘤有较好的临床疗效,明显提高患者的细胞免疫功能,且改善生活质量.

Clinical effects of cytokine induced killer cells treatment combined with radiofrequency ablation on liver metastases

Objective To observe the efficacy of cytokine induced killer (CIK) cells combined with radiofrequency ablmion (RFA) in treatment of liver metastases.Methods 23 patients were treated with CIK plus RFA, while 27 patients with RFA.Tumot markers and CD3+、CD4+、CD8+、CD4+/CD8+ were tested before and after treatment.Recurrence rate and Kamofsky score were also evaluated.Results The local recurrence rate in the study group was lower (13.04% vs.40.74%)(P<0.05),CD3+、CD4+、and CD4+/CD8+ were increased (P<0.01). The percentage of patients with decreased tumor markers and increased Kamofsky is higher (P<0.05);Conclusion The therapy of CIK combined with RFA has better efficacy on liver metastases,can enhance the cellular immune functions and improve the quality of life significantly.