Novel t(8;17)(q23;q24.2) and t(9;22)(p24.1;q12.2) in acute megakaryoblastic leukemia AML-M7 subtype in an adult patient |
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| Authors: | Firoz Ahmad Rupa Dalvi Bibhu Ranjan Das Swarna Mandava |
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| Affiliation: | aResearch and Development, Super Religare Laboratories, Mumbai 400093, India;bCytogenetic Division, Super Religare Laboratories (formerly SRL Ranbaxy), Plot No. 124, 17th Street, MIDC, Andheri (E), Mumbai 400093, India |
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| Abstract: | The strong association of diagnostic karyotype with clinical outcome has made cytogenetics one of the most valuable diagnostic and prognostic tools for acute myeloid leukemia (AML). The subtype M7 is a rare disease of the megakaryoblastic lineage and is mostly associated with complex abnormal karyotype. We describe the clinical, morphologic, immunophenotypic, and cytogenetic findings in the case of a 39-year-old man with acute megakaryoblastic leukemia (AML-M7). Cytogenetic analysis revealed two translocations, t(8;17)(q23;q24.2) and t(9;22)(p24.1;q12.2), at presentation; to our knowledge, this combination is a novel finding for acute megakaryoblastic leukemia. The patient responded to induction therapy, achieving complete remission after 9 days of therapy. |
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