不同海拔高度居住高原不同时间健康青年血浆内皮素和一氧化氮的测定

本文对从平原（海拔1400m）进驻海拔3700m和5380m高原第7天及半年的56名官兵进行血浆内皮素（ET）和一氧化氮（NO）检测，并与20名平原健康青年作对照。结果：进驻海拔3700m和5380m第7天和半年，ET均较平原增高非常显著（P＜0．01），NO在进驻5380m第7天和半年及3700m第7天时较平原降低非常显著（P＜0．01），3700m居住半年时较平原无显著性差异（P＞0．05）。进驻高原第7天及半年，5380m较3700mET增高非常显著（P＜0．01），NO降低非常显著（P＜0．01）。进驻3700m和5380m，第7天较半年ET显著增高（P＜0．05或P＜0．01），NO降低显著（P＜0．05）。结论：作者认为低NO和高ET血症可能是高原低氧引起肺动脉高压的重要原因之一。

Determination of plasma endothelin and nitric oxide on healthy youth under the different elevation and different living time

Plasma endothelin (ET) and nitric oxide (NO ) of 56 young people were determined when they arrived on high altitude (3700m ) and higher elevation (5800m)from plain (1400m)for 7 days and 6 months, and are compared with 20 healthy youths in plain. The results show: entering high altitude for the seventh day and 6 months, ET increases very obviously (P< 0.01), NO decreases notably (P<0.01 ),but there is no notable discrepancy when they arrived at 3700m for 6 months (P> 0.05). At 5380m ,ET increased obviously than at 3700m (P<0.01), NO decreased notably (P <0.01); entering high altitude,the ET of the seventh day is higher than that of 6 months, NO is lower (P<0.05 ).The writers consider that: hyponitric oxide and hyperendothelin is perhaps one of the reasons of pulmonary hypertension which is caused by altitued hypoxia.