| 血清ICTP、PICP、PINP的检测对原发性肝癌骨转移的诊断意义 |
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| 引用本文： | 周晓东,杨晶侠,房殿春,刘为纹.血清ICTP、PICP、PINP的检测对原发性肝癌骨转移的诊断意义[J].肿瘤研究与临床,1998(2). |
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| 作者姓名： | 周晓东 杨晶侠 房殿春 刘为纹 |
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| 作者单位： | 解放军３２２医院，第三军医大学西南医院 |
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| 摘 要： | 为了研究血清ＩＣＴＰ、ＰＩＣＰ和ＰＩＩＮＰ的水平与原发性肝癌骨转移的关系，采用放射免疫法检测了５０例原发性肝癌（骨转移３０例，无骨转移２０例）及２０例健康者血清中ＩＣＴＰ、ＰＩＣＰ和ＰＩＮＰ的水平，结果发现，原发性肝癌患者血清ＩＣＴＰ、ＰＩＮＰ显著高于健康者（Ｐ＜０．０１和Ｐ＜０．０５），其中伴骨转移的原发性肝癌血清ＩＣＴＰ、ＰＩＮＰ显著高于无骨转移者（Ｐ＜０．０１），但ＰＩＣＰ则无显著性差异，提示ＩＣＴＰ和ＰＩＮＰ可作为原发性肝癌的预后判断指标，尤其可作为原发性肝癌发生骨转移的判断指标。
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| 关 键 词： | 原发性肝癌 骨转移 Ⅲ型前胶原氨基末端前肽 Ⅰ型胶原羧基末端终肽 Ⅰ型前胶原羧基末端前肽 |
THE DIAGNOSTIC SIGNIFICANCE OF ICTP, PICP AND PIINP IN PRIMARY HEPATIC CANCER WITH BONE METASTASIS |
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| Zhou Xiaodong,Yang Jingxia,Fang Dianchun,et al The hospital of PLA.THE DIAGNOSTIC SIGNIFICANCE OF ICTP, PICP AND PIINP IN PRIMARY HEPATIC CANCER WITH BONE METASTASIS[J].Cancer Research and Clinic,1998(2). |
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| Authors: | Zhou Xiaodong Yang Jingxia Fang Dianchun The hospital of PLA |
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| Institution: | Zhou Xiaodong,Yang Jingxia,Fang Dianchun,et al The 322 hospital of PLA |
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| Abstract: | In order to investigate the relationship between ICTP, PICP, PIINP and bone metastasis of primary hepatic cancer(PHC), The serum concentration of ICTP, PICP, and PIINP were detected in 50 casea of PHC(30 cases with bone metastasis, 20 cases without bone metasasis) and 20 normal controls by using the radioimmunoassay. The ICTP and PIINP in PHC were significantly higher than that in normal controls( P <0.01 and P <0.05). The level of ICTP and PIINP in bone metastasis group were significantly higher than that without bone metastasis ( P <0.01). The ICTP and PIINP decreased remarkably after chemotherapy in bone metastasis group ( P <0.05). The results suggested that the ICTP and PIINP may be as prognostic markers for evaluation of PHC, espically for PHC with bone metastasis. |
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