Hepatitis A virus and non-A, non-B virus superinfections in HBsAg chronic carriers |
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| Authors: | D E Sansonno G Fiore F Pietropaolo D Avellis N Napoli O G Manghisi |
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| Affiliation: | Laboratory of Liver Immunopathology, Istituto di Ricovero e Cura a Carattere Scientifico, Castellana Grotte, Bari, Italy. |
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| Abstract: | Clinical course, morphologic changes, immunohistochemical localization of HBV-associated markers (HBsAg, HBcAg), and serum HBV-DNA production are described in 2 chronic HBsAg carriers superinfected with HAV and hepatitis non-A, non-B virus. Our data suggest that the superinfections do not cause more severe disease and do not influence the clinical course of the HBsAg chronic carriers. Our observations indicate that a careful diagnosis of hepatocytolysis is necessary in HBV chronic infection, in order to discriminate causes that are able to induce severe damage in underlying disease. |
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