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| HPLC法测定复方五味子安神胶囊中五味子甲素的含量 | |
| 引用本文： | 李可,钟新忠,吴明东,廖华卫.HPLC法测定复方五味子安神胶囊中五味子甲素的含量[J].中国药师,2010,13(6):817-818. |
| 作者姓名： | 李可 钟新忠 吴明东 廖华卫 |
| 作者单位： | 1. 茂名市茂南区人民医院,广东茂名,525011 2. 茂名市人民医院 3. 广东药学院中药学院 |
| 摘 要： | 目的：建立高效液相色谱法测定复方五味子安神胶囊中五味子甲素含量的方法.方法：采用 Kromasil C18（250mm×4.6 mm,5 μm）色谱柱 以甲醇-0.1%冰醋酸水溶液（80：20）为流动相 流速：1 ml·min-1 检测波长：254 nm 柱温为30℃.结果：五味子甲素在0.1014～0.4056 mg·ml-1范围内与峰面积分别呈良好的线性关系（r=0.999 7,n=6）,平均回收率是100.7%（RSD=0.5%）.结论：本方法简便、准确、专属性强,可用于该制剂的质量控制. |
| 关 键 词： | 高效液相色谱法 复方五味子安神胶囊 五味子甲素 |
Determination of Deoxyschizandrin in Compound Wuweizi Anshen Capsules by HPLC |
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| Li Ke,Zhong Xinzhong,Wu Mingdong,Liao Huawei.Determination of Deoxyschizandrin in Compound Wuweizi Anshen Capsules by HPLC[J].China Pharmacist,2010,13(6):817-818. | |
| Authors: | Li Ke Zhong Xinzhong Wu Mingdong Liao Huawei |
| Institution: | 1. People＇ s Hospital of Maonan District in Maoming City, Guangdong Maoming 525011 ,China;2. People＇s Hospital of Maoming City;3. School of Traditional Chinese Medicine,Guangdong Pharmaceutical University) |
| Abstract: | Objective： To set up a determination of deoxyschizandrin in compound wuweizi anshen capsules by HPLC. Method： The KromasilCl8 （250 mm×4.6 ram, 5 μm） column was used with methanol-0. 1% acetic acid solution （80： 20） as mobile phase. The flow rate was 1 ml- min- 1 and the detection wavelength was 254 nm, the temperature of column was 30 ℃. Result： The linear range of deoxyschizandrin was 0. 101 4-0. 405 6 mg·ml-1（r =0. 999 7 ,n =6） and the average recovery was 100. 7% with RSD 0. 5% for deox- ysehizandrin. Conclusion： The method is simple, accurate and rapid with good reproducibility,it can be used for the quality control of eomoound wuweizi anshen capsules. |
| Keywords: | HPLC Compound wuweizi anshen capsules Deoxyschizandrin |
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