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Changes in the Cytokine Profile and Reduced Function of Lymphocyte Subpopulations in Subacute Tetrachloromethane Poisoning |
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| Authors: | P. F. Zabrodskii V. F. Kirichuk V. G. Lim S. V. Balashov A. A. Svistunov |
| Affiliation: | (1) Saratov State Medical University, Saratov, Russia |
| Abstract: | Experiments on outbred albino rats showed that subacute poisoning with tetrachloromethane in a total dose of 1.0 LD50 appreciably decreased blood concentrations of cytokines (IFN-γ, IL-2, IL-4, IL-6, IL-10), reduced the IFN-γ/IL-4 ratio in comparison with the control, and suppressed the immune reactions, which attests to greater damage to Th1 compared to Th2 lymphocytes. Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 147, No. 1, pp. 55-57, January, 2009 |
| Keywords: | tetrachloromethane immunotoxicity cytokines Th1, Th2 lymphocytes |
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