可生物降解共聚膜修复兔桡骨节段性缺损

目的：探讨在引导性骨再生中生物降解材料聚已内酯（ｐｏｌｙ ε ｃａｐｒｏｌａｃｔｏｎｅ， Ｐ Ｃ Ｌ）和聚乳酸（ｐｏｌｙ ｌａｃｔｉｃ ａｃｉｄ， Ｐ Ｌ Ａ）共聚物的作用及其生物相容性和生物降解性。方法：采用兔桡骨中段１２ ｃｍ节段性骨缺损（保留骨膜）动物模型，共２４只分两组进行对照研究，每组１２只，双侧处理方法相同， Ａ组骨缺损区用膜包绕骨缺损区， Ｂ 组为空白对照。分别于３、６、１２周后处死，进行 Ｘ 线、大体、组织学及电镜观察，检测生化及免疫指标。结果：实验组（ Ａ）骨生长明显优于对照组（ Ｂ）；材料呈明显的降解趋势；血清中 Ｃａ、 Ｐ、 Ｉｇ Ｇ、 Ｉｇ Ｍ 、 Ｃ４值与正常及空白对照均无明显差异。结论：生物降解材料（ Ｐ Ｃ Ｌ／ Ｐ Ｌ Ａ）在引导骨性组织再生中有良好的屏障作用，促进骨缺损的愈合。证明新型骨生物降解材料有良好的生物降解性和生物相容性。

Repair of radial segmental defects using biodegradable coplymer membranes:an experimental study in rabbits

Objective:To explore the role of biodegradable PLA/PCL copolymer membrane in repairing longbone segmental defects by using guided bone regeneration(GBR),and to investigate biocompatible and degradable of the material.Methods:1.2 cm rabbit radial segmental defects (retaining the periosteum) were created in this study, 24 animals were divided into 2 groups,and the same method were applied in bilateral radius.Membrane around the defects were used in group A;Group B served as control.Four animals in each group were put to death after 3,6 and 12 weeks respectively after operation.X ray films were taken and the macromorphology and histology were observed.The surface and cross section of the implant materials were scanned by electron microscope.Biochemical and immunological data were collected. Results:The bone regeneration of group A was better than that of the control group (B).The implant materials showed prominent tendency of degradation.There was no difference in the serum Ca,P,ALP,IgG,IgM and C 4.between the two groups.Conclusion:The biodegradable membrane as a barrier can enhance bone regeneration.And satisfactory biocompatibility and degradation are also be proved.