Chronic heart failure in the guinea pig increases cardiac alpha 1- and beta-adrenoceptors |
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| Authors: | J S Karliner P Barnes M Brown C Dollery |
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| Affiliation: | Department of Clinical Pharmacology, Royal Postgraduate Medical School, DuCane Road, London W12, U.K. |
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| Abstract: | Compared with sham-operated guinea pigs, chronic heart failure produced by aortic constriction resulted in a 79% increase in alpha 1-adrenoceptor density as measured by [3H]prazosin binding (73 +/- 15 vs. 131 +/- 20 fmol/mg protein, P < 0.05); beta-adrenoceptor number, measured by (-)-[3H]dihydroalprenolol binding, increased by 93% (28 +/- 3.4 vs. 54 +/- 5.2 fmol/mg protein, P < 0.01). For each radioligand KD values were unchanged. Thus, congestive heart failure due to chronic pressure overload results in compensatory augmentation of alpha 1- and beta-adrenoceptor numbers. |
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| Keywords: | Aortic constriction β-Adrenoceptors Chronic heart failure Fogarty Senior International Fellow to whom correspondence should be addressed at the Division of Cardiology, University Hospital, 225 Dickinson Street, San Diego, California, 92103, U.S.A. |
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