| 乳腺癌组织抑癌基因PTEN的表达及其意义 |
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| 引用本文： | 邓军,吴礼高,陈勇,喻大军.乳腺癌组织抑癌基因PTEN的表达及其意义[J].实用全科医学,2008,6(6):555-556. |
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| 作者姓名： | 邓军 吴礼高 陈勇 喻大军 |
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| 作者单位： | [1]安徽省蚌埠医学院附属医院肿瘤外科,233000 [2]蚌埠医学院病理教研室,233000 |
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| 基金项目： | 安徽省高校省级自然科学基金 |
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| 摘 要： | 目的研究抑癌基因PTEN在乳腺癌中的表达及其临床意义。方法采用免疫组化技术（S-P）检测72例乳腺癌中PTEN的表达情况。结果PTEN总的表达缺失率为62.5%（45/72）。PTEN表达缺失率与乳腺癌的组织学分级,TNM临床分期,腋窝淋巴结转移和生存时间有关（P〈0.05）,而与肿瘤的大小和ER、PR状况无关。结论检测乳腺癌PTEN在蛋白水平的表达缺失状况可能有助于对其预后的判断。
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| 关 键 词： | 抑癌基因PTEN 免疫组织化学 乳腺癌 |
| 文章编号： | 1672-1764(2008)06-0555-02 |
| 修稿时间： | 2008年3月8日 |
Expression and Significance of the Tumor Suppressor Gene PTEN in Breast Cancer |
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| Institution: | DENG Jun, WU Li-gao, CHEN Yong,et al,( Department of Tumor Surgery,Affiliated Hospital of Bengbu Medical College,Anhui 233000, China) |
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| Abstract: | Objective To study the expression and clinical significance of tumor suppressor gene PTEN in breast cancer. Methods Immunohistochemieal staining（S-P） was used to detect the expression of PTEN in 72 cases of breast cancer samples. Results Among these 72 samples,the rates of total expressing depletion of PTEN were 62.5% （45/72）. The rates of total expressing depletion of PTEN was significantly correlated with histological grade, TNM staging,axillary lymph nodes status and survival time （ P 〈 0.05 ）, but not with tumor size, estrogen and progesterone receptors. Conclusions The depletion of the expression of PTEN at protein level may contribute to prognostic criterion for breast cancer |
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| Keywords: | Tumor suppressor gene PTEN Immunohistochemistry Breast cancer |
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