半夏泻心汤调节胃肠动力的物质基础研究

目的:探讨半夏泻心汤调节胃肠动力的物质基础。方法:正常大鼠、阿托品致胃肠动力障碍大鼠、慢性水浸束缚致胃肠动力障碍大鼠分别ig给予蒸馏水、多潘立酮(0.01 g·kg-1)、半夏泻心汤(2 g·kg-1)、辛开药液(1.5 g·kg-1)、苦降药液(1.5 g·kg-1)、甘补药液(1.5 g·kg-1),连续4 d,通过测定大鼠胃残留率、小肠推进率筛选半夏泻心汤调节胃肠动力的有效药物组分;灌胃蒸馏水、多潘立酮(0.01 g·kg-1)、半夏泻心汤醇沉药液(2 g·kg-1)、半夏泻心汤醇沉水溶药液(2 g·kg-1)、苦降醇沉药液(1.5 g·kg-1)、苦降醇沉水溶药液(1.5 g·kg-1),同法筛选其有效部位。结果:与正常大鼠比较,两种模型大鼠,胃残留率明显上升,小肠推进率明显下降,且均有统计学意义(P0.05,P0.01);在给予不同药液后,两项指标均有不同程度的变化,其中半夏泻心汤能降低阿托品模型大鼠胃残留率,半夏泻心汤醇沉药液、苦降药液和苦降醇沉药液能降低正常大鼠和两种模型大鼠的胃残留率,以上变化均具有统计学意义(P0.05,P0.01)。结论:半夏泻心汤有调节胃肠动力的作用,其有效药物组分主要为苦降药组,其有效部位为苦降药的醇沉部位。

Study on Material Basis of Banxia Xiexin Tang in Regulating Gastrointestinal Motility

Objective: To explore the material basis of Banxia Xiexin Tang in regulating gastrointestinal motility. Method: The two kinds of model were established by subcutaneous injection of atropine sulfate and chronic water immersion stress respectively.Domperidone(0.01 g·kg^-1), Banxia Xiexin Tang(2 g·kg^-1), pungent drugs, bitter drugs and tonic with sweet drugs(1.5 g·kg^-1) were orally given for 4 days. The remnant rate of stomach and progradation rate of small intestine were measured. Result: Compared with normal group, the gastric retention rate of model group increased, and the small intestinal propulsion decreased. The difference was statistically significant(P<0.05, P<0.01). When the model rats were orally given different drugs, both of the 2 indicators had different degrees of change. The banxia xiexin decoction decreased the gastric retention rate of the model rats. The ethanol precipitation of Banxia Xiexin Tang, the bitter drugs and the ethanol precipitation of bitter drugs decreased the gastric retention of normal rats and the two kinds of model rats. The difference was statistically significant (P<0.05, P<0.01). Conclusion: Banxia Xiexin Tang may be play the role of regulating gastrointestinal motility, the bitter drugs for purgation are the effective group mainly and the ethanol precipitation parts are the effective components.