Haematological and hormonal responses to dynamic exercise in patients with chronic airway obstruction |
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Authors: | M. GIMENEZ ,T. MOHAN-KUMAR&dagger ,J.-C. HUMBERT&Dagger ,NICOLE DE TALANCE§ ,M. TEBOUL&Dagger ,J. L. PONZy&dagger ,J. M. POLU |
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Affiliation: | *Laboratoire de Physiologie de l'Exercise Musculaire, Institut de la Santéet de la Recherche Médicale;‡Service de Cytologie, Centre Régional de Transfusion Sanguine et Hématologie;§Laboratoire de Physiologie Humaine, section du métabolisme hydrominéral;**Service de Médecine orientée vers l'insuffisance respiratoire, Centre Hospitalier Universitaire de Brabois, Vandoeuvre-les-Nancy, France.;†Pulmonary fellows in training: T. Mohan-Kumar, Pazhayanur (India) and J. L. PONZ, Madrid (Spain). |
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Abstract: | The influence of exercise on hormonal and total white blood cells (WBC), lymphocytes (L). Granulocytes (GR), and platelet (P) count responses was studied in: twenty-five patients with chronic airway obstruction (CAO, 47 +/- 1.8 years, mean +/- SEM) and thirteen normal subjects (N, 36 +/- 2.6 years). They performed a submaximal (40 W) and a maximal exercise (VO2max). Arterial blood samples were taken at rest, 40 W, and VO2max. [H+], PaCO2, PaO2 haematocrit (Hct), [Hb], P, total platelet volume (TPV), WBC, GR, L, and total red blood cells (RBC) were measured. At rest, WBC, GR, P and TPV were higher in CAO patients, whilst PaO2 and cortisol were lower. At 40 W, when compared to values obtained at rest, WBC, GR, L, P and TPV were increased in both groups; WBC, GR, P and TPV were higher in CAO patients. VO2max of CAO patients represented 54% of that of controls. At VO2max, Hct, [Hb] and RBC were approximately 10% higher than at rest in both groups, whilst changes were more significant in normals for WBC (CAO = 55%, N = 76%), lymphocytes (CAO = 83%, N = 105%), GR, (CAO = 37%; N = 51%), platelets (CAO = 23%, N = 29%), TPV (CAO = 25.4%, N = 35%), [H+] (CAO = 43%, N = 38%) and ACTH (CAO = 82%, N = 139%). PaO2 and cortisol did not differ between groups. PaCO2 and platelets however, were higher in the CAO group.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Keywords: | White blood cells lymphocytes platelets haemoglobin cortisol ACTH arterial blood gases chronic bronchitis normal men exercise testing V`O2max |
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