脑梗死患者颈动脉粥样硬化斑块和血清MMP-9的临床研究

目的探讨脑梗死患者颈动脉粥样硬化斑块与血清基质金属蛋白酶-9（MMP-9）水平的关系。方法选取48例确诊为脑梗死患者为研究组．30例健康查体者为对照组。两组均抽取空腹血测血清MMP-9水平及行颈动脉彩超检查。结果脑梗死组颈动脉斑块检出率为72．9％，明显高于对照组的40．O％，差异有统计学意义（P〈0．05）；脑梗死组中MMP-9的表达为（284．23±132．58）ng／mL，明显高于对照组的（96．45±32．63）ng／mL，差异有统计学意义（P〈0．05）；脑梗死组中的不稳定斑块为17例（48．57％），明显高于对照组的1例（8．33％），差异有统计学意义（P〈0．05）；不稳定斑块组中MMP-9的表达为（482．63±158．79）ng／mL，明显高于稳定斑块组的（232．64±109．35）ng／mL，差异有统计学意义（P〈0．05）。结论脑梗死患者的颈动脉粥样硬化斑块发生率明显增高，血清MMP-9水平与颈动脉粥样硬化斑块形成有关，可以反映颈动脉粥样硬化斑块的稳定性。

The clinical study between carotid artery atherosclerotic plaque and serum matrix metalloproteinase-9 level in cerebral infarction patients

Objective To investigate the relationship between cerebral infarction in patients with carotid artery atherosclerotic plaque and serum matrix metalloproteinase-9(MMP-9) levels.Methods Forty-eight cases of diagnosed patients were selected as cerebral infarction group,30 cases of healthy subjects as control group.Two groups were taken from the fasting blood measurement of serum MMP-9 level and carotid color Doppler ultrasound examination.Results The cerebral infarction group carotid plaque detection rate(72.9%) was significantly higher than that of control group(40.0%),the difference was statistically significant(P < 0.05);MMP-9 expression in the cerebral infarction group(284.23±132.58) ng/mL was significantly higher than control group(96.45±32.63) ng/mL,the difference between the two groups was also significant(P < 0.05);cerebral infarction group stable plaque in 17 cases(48.57%) was significantly higher than one cases(8.33%),the difference was statistically significant(P < 0.05);the expression of MMP-9 in the unstable plaque group(482.63±158.79) ng/mL,was significantly higher than the stable plaque group(232.64±109.35) ng/mL,the difference was statistically significant(P < 0.05).Conclusion The carotid atherosclerotic plaque rate was significantly higher in cerebral infarction patients,there is a relationship between the serum MMP-9 levels and carotid atherosclerotic plaque formation,may reflect the stability of the carotid atherosclerotic plaque.