急性脑梗死患者治疗前后血NSE、GST的检濒及其临床意义

目的探讨急性脑梗死患者治疗前后血NSE、GST的检测及其临床意义。方法选取2009年12月-2011年12月在我院确诊的50例急性脑梗死患者作为脑梗死组。同时选取同期在我院进行体检并证实为健康人40例作为正常对照组。NSE的检测采用电化学发光免疫法，血清GST测定采用ELISA法。结果治疗前脑梗死组NSE、GST与对照组比较差异有统计学意义（P〈0．05）；治疗后1周，脑梗死组NSE、GST分别与治疗前、对照组比较差异有统计学意义（P〈0．05）；治疗后2周，脑梗死组NSE、GST分别与治疗前、治疗后1周比较差异有统计学意义（P〈0．05）；治疗后2周，脑梗死组NSE、GST分别与对照组比较差异有统计学意义（P〈0．05）。随着治疗时间的延长，NSE水平较治疗前逐渐降低，GST水平较治疗前明显升高，血浆NSE及血清GST含量变化呈负相关（r=-0．5378，P〈0．05）。结论NSE及GST的检测对急性脑梗死患者病变严重程度及预后评估具有重要的临床意义。

Before and after treatment of acute cerebral infarction blood NSE and GST detection and its clinical significance

Objective To investigate blood NSE and GST detection and its clinical significance of acute cerebral infarction patients before and after treatment.Methods From December 2009 to December 2011 in our hospital,confirmed a total of 50 cases of acute cerebral infarction cerebral infarction group.Selected the same period in our hospital to undergo a medical examination and confirmed 40 cases as a normal control group of healthy people.NSE was detected by electrochemilumine scence immunoassay,serum GST was determined by ELISA method.Results Pre-treatment of cerebral infarction group of NSE,GST and normal control group,the difference was statistically significant(P < 0.05),one week after treatment,cerebral infarction group of NSE,GST and pre-treatment,respectively,compared with the normal control group,the difference statistically significant(P < 0.05),two weeks after treatment,the cerebral infarction group of NSE and GST,respectively,and before treatment,after treatment,one week,the difference was statistically significant(P < 0.05).Two weeks after the treatment of cerebral infarction group NSE GST with the normal control group,the difference was statistically significant(P < 0.05),with the extension of treatment time,NSE levels than before treatment decreased of GST levels before treatment l plasma NSE and serum GST content was negatively correlated(r =-0.5378,P < 0.05).Conclusion NSE and GST detection of severity and prognostic evaluation of patients with acute cerebral infarction lesions has important clinical significance.